{"created":"2025-02-21T03:58:14.269995+00:00","id":2007634,"links":{},"metadata":{"_buckets":{"deposit":"79dc0701-8773-43bf-a11c-e6b79812b9cd"},"_deposit":{"created_by":41,"id":"2007634","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2007634"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02007634","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"High-Density Protein Loading on Hierarchically Porous LDH-Aluminum Hydroxide Composites with a Rational Mesostructure","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tokudome, Yasuaki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Tokudome","familyNameLang":"en"}],"givenNames":[{"givenName":"Yasuaki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Fukui, Megu","creatorNameLang":"en"}],"familyNames":[{"familyName":"Fukui","familyNameLang":"en"}],"givenNames":[{"givenName":"Megu","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tarutani, Naoki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Tarutani","familyNameLang":"en"}],"givenNames":[{"givenName":"Naoki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nishimura, Sari","creatorNameLang":"en"}],"familyNames":[{"familyName":"Nishimura","familyNameLang":"en"}],"givenNames":[{"givenName":"Sari","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Prevot, Vanessa","creatorNameLang":"en"}],"familyNames":[{"familyName":"Prevot","familyNameLang":"en"}],"givenNames":[{"givenName":"Vanessa","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Forano, Claude","creatorNameLang":"en"}],"familyNames":[{"familyName":"Forano","familyNameLang":"en"}],"givenNames":[{"givenName":"Claude","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Poologasundarampillai, Gowsihan","creatorNameLang":"en"}],"familyNames":[{"familyName":"Poologasundarampillai","familyNameLang":"en"}],"givenNames":[{"givenName":"Gowsihan","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Lee, Peter D.","creatorNameLang":"en"}],"familyNames":[{"familyName":"Lee","familyNameLang":"en"}],"givenNames":[{"givenName":"Peter D.","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Takahashi, Masahide","creatorNameLang":"en"}],"familyNames":[{"familyName":"Takahashi","familyNameLang":"en"}],"givenNames":[{"givenName":"Masahide","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2016 American Chemical Society"},{"subitem_rights":"This document is the Accepted Manuscript version of a Published Work that appeared in final form in Langmuir, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.langmuir.6b01925"},{"subitem_rights":"This is not the published version. Please cite only the published version. この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Hierarchically porous biocompatible Mg-Al-Cl type LDH composites containing aluminum hydroxide (Alhy) have been prepared using a phase-separation process. The sol-gel synthesis allows for the hierarchical pores of the LDH-Alhy composites to be tuned, leading to a high specific solid surface area per unit volume available for high molecular weight protein adsorptions. A linear relationship between effective surface area, SEFF, and loading capacity of a model protein, bovine serum albumin (BSA) is established following successful control of the structure of the LDH-Alhy composite. The threshold of mean pore diameter, Dpm, above which BSA is effectively adsorbed on the surface of LDH-Alhy composites, is deduced as 20 nm. In particular, LDH-Alhy composite aerogels obtained via supercritical drying exhibits extremely high capacity for protein loading (996 mg/g) due to a large mean mesopore diameter (> 30 nm). The protein loading on LDH-Alhy is >14 times that of a reference LDH material (70 mg/g) prepared via a standard procedure. Importantly, BSA molecules pre-adsorbed on porous composites were successfully released on soaking in ionic solutions (HPO42− and Cl− aq.). The superior capability of the biocompatible LDH materials for loading, encapsulation, and releasing large quantity of proteins was clearly demonstrated, which potential uses in separation and purification in addition to a high-capacity storage medium.","subitem_description_language":"en"},{"subitem_description":"The present work is supported by JSPS-MAE SAKURA program (N°34148TB).","subitem_description_type":"Other"},{"subitem_description":"The present work is partially supported by JSPS KAKENHI, and by a research grant from the Foundation for the Promotion of Ion Engineering.","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"American Chemical Society"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"1520-5827","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA10461730","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"8826"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-08-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"35","bibliographicPageEnd":"8833","bibliographicPageStart":"8826","bibliographicVolumeNumber":"32","bibliographic_titles":[{"bibliographic_title":"Langmuir","bibliographic_titleLang":"en"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_b1a7d7d4d402bcce","subitem_version_type":"AO"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1021/acs.langmuir.6b01925","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1021/acs.langmuir.6b01925","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"Langmuir_32_8826.pdf","filesize":[{"value":"1.4 MB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2007634/files/Langmuir_32_8826.pdf"},"version_id":"15098a06-a447-4630-ae81-8459e0ec1b7f"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"53531"},"item_title":"High-Density Protein Loading on Hierarchically Porous LDH-Aluminum Hydroxide Composites with a Rational Mesostructure","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2007634","relation_version_is_last":true,"title":["High-Density Protein Loading on Hierarchically Porous LDH-Aluminum Hydroxide Composites with a Rational Mesostructure"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-21T10:33:34.957993+00:00"}