| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
High frequency of open-angle glaucoma in Japanese patients with Alzheimer's disease |
|
言語 |
en |
| 作成者 |
Tamura, Hiroki
Kawakami, Hideshi
Kanamoto, Takashi
Kato, Tomoko
Yokoyama, Tomoko
Sasaki, Ken
Izumi, Yuishin
Matsumoto, Masayasu
Mishima, Hiromu K.
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2006 Elsevier Ltd. |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Alzheimer's disease (AD) |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Open-angle glaucoma (OAG) |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Apolipoprotein E (APOE) |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Intraocular pressure (IOP) |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Japanese |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Prevalence |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Polymorphism |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
The clinical and genetic relationships between Alzheimer's disease (AD) and glaucoma remain obscure. The aim of this study was to determine the prevalence of open-angle glaucoma (OAG) in patients with AD and whether the apolipoprotein E (APOE) 4 allele is associated with AD, with or without OAG, in Japanese. The groups consisted of 172 patients with the diagnostic criteria of AD and 176 age-matched controls. Ophthalmic examinations were conducted, and genomic analysis was performed by PCR and digestion of products with an enzyme. OAG was found in 41 (23.8%) of the AD patients, which was a significantly (p=0.0002) higher prevalence than that in the controls (9.9%). Furthermore, there was no significant difference between intraocular pressures (IOPs) in AD patients with OAG and without OAG. The percentage of AD patients who carried an APOE ε4 allele (29.5%) was significantly (p=0.0007) higher than that of the controls (9.1%). However, the percentage of AD patients with OAG who carried an APOE ε4 allele (35.7%) was not significantly different than that of AD patients without OAG (27.7%, p=0.42). In summary, the prevalence of OAG is high in Japanese patients with AD, suggesting that common factors other than APOE may contribute to the two diseases. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Elsevier |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.jns.2006.02.009 |
| 関連情報 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
16564058 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1016/j.jns.2006.02.009 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0022-510X |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00703265 |
| 開始ページ |
|
|
開始ページ |
79 |
| 書誌情報 |
Journal of the Neurological Sciences
Journal of the Neurological Sciences
巻 246,
号 1-2,
p. 79-83,
発行日 2006-07-15
|
| 旧ID |
17103 |
JNeuroSci_246_79.pdf (233.3 KB)
