| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Alterations in the hippocampal glycinergic system in an animal model of posttraumatic stress disorder |
|
言語 |
en |
| 作成者 |
Yamamoto, Shigeto
Morinobu, Shigeru
Iwamoto, Yasuyuki
Ueda, Yuto
Takei, Shiro
Fujita, Yosuke
Yamawaki, Shigeto
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2010 Elsevier Ltd. |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Single prolonged stress |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Fear extinction |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Glycine |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Glycine transporter 1 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Hippocampus |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Posttraumatic stress disorder |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Previous studies have demonstrated that rats subjected to single prolonged stress (SPS) exhibit posttraumatic stress disorder (PTSD)-like symptoms such as enhanced contextual fear in response to trauma related and trauma-unrelated events Furthermore we previously reported that upregulation of hippocampal glycine transporter 1 (GlyT-1) mRNA after context exposure could be the initial mechanism underlying impaired fear extinction in SPS rats To clarify the involvement of the hippocampal glycinergic system in impaired fear extinction in SPS rats we measured the time course of changes in the duration of freezing, and the hippocampal levels of Gly-T1 mRNA using contextual fear conditioning (FC) and extinction training We also used in vivo microdialysis to measure the concentration of extracellular glycine in the hippocampus during the time interval between FC and the first context exposure SPS rats exhibited increased and sustained contextual fear responses The enhanced contextual fear response in SPS rats was associated with a sustained increase in hippocampal levels of Gly-T1 mRNA after FC relative to sham rats and by a decrease in the extracellular glycine concentration GlyT-1 mRNA levels in rats that underwent repeated extinction training were significantly lower than in rats that did not undergo extinction training These findings indicate that reduced activity of the hippocampal glycinergic system could be closely involved in impaired fear extinction in SPS rats suggesting that activation of the glycinergic system by D-cycloserine or GlyT-1 inhibitors may ameliorate the impairment of fear extinction. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Pergamon Elsevier Science Ltd |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.jpsychires.2010.03.013 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1016/j.jpsychires.2010.03.013 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0022-3956 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00705646 |
| 開始ページ |
|
|
開始ページ |
1069 |
| 書誌情報 |
Journal of Psychiatric Research
Journal of Psychiatric Research
巻 44,
号 15,
p. 1069-1074,
発行日 2010-11
|
| 旧ID |
30879 |
JPsychiatrRes_44_1069.pdf (127.7 KB)
