| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
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|
タイトル |
Focal adhesion kinase mediates human leukocyte histocompatibility antigen class II-induced signaling in gingival fibroblasts |
|
言語 |
en |
| 作成者 |
Yoshizawa, S.
Meguro, M.
Ohyama, H.
Takeuchi-Hatanaka, K.
Matsushita, S.
Takashiba, S.
Nishimura, Fusanori
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| アクセス権 |
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|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
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|
権利情報 |
Copyright(c) 2007 Blackwell Publishing |
| 主題 |
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|
主題Scheme |
Other |
|
主題 |
focal adhesion kinase |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
gingival fibroblast |
| 主題 |
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|
主題Scheme |
Other |
|
主題 |
human leukocyte antigen-II |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
luteolin |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
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|
内容記述 |
Background and Objective: The role of human leukocyte antigen class II molecules on nonantigen-presenting cells has been a matter of controversy. We previously reported that human leukocyte antigen class II molecules on human gingival fibroblasts do not present antigens, but transduce signals into the cells by making a complex with antigenic peptide T-cell receptor or by stimulating cell surface human leukocyte antigen-DR molecules with human leukocyte antigen-DR antibody (L243), which mimics the formation of the human leukocyte antigen class II-antigenic peptide T-cell receptor complex, resulting in the expression of several cytokines. The aim of this study was to detect human leukocyte antigen class II-associated molecules mediating human leukocyte antigen class II-induced signals into the cells. Material and Methods: Antibody-based protein-microarray analysis was performed to detect activated signaling molecules in gingival fibroblasts stimulated via human leukocyte antigen class II molecules. Then, we examined if these molecules structurally associate with human leukocyte antigen class II and actually transduce signals into the cells. Results: Stimulation of human leukocyte antigen class II on gingival fibroblasts by L243 resulted in enhanced phosphorylation of focal adhesion kinase. Focal adhesion kinase was co-immunoprecipitated with human leukocyte antigen-DR by L243. Stimulation of gingival fibroblasts with L243 induced phosphorylation of focal adhesion kinase. Luteolin, a putative focal adhesion kinase inhibitor, suppressed phosphorylation of focal adhesion kinase and dose dependently inhibited human leukocyte antigen class II-induced cytokine production. Conclusion: Focal adhesion kinase is structurally associated with human leukocyte antigen-DR and mediates human leukocyte antigen class II-induced signals in gingival fibroblasts. |
|
言語 |
en |
| 出版者 |
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|
出版者 |
Blackwell Publishing |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
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|
関連名称 |
The definite version is avairable at www.blackwell-synergy.com |
| 関連情報 |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
10.1111/j.1600-0765.2007.00985.x |
| 関連情報 |
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|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1111/j.1600-0765.2007.00985.x |
| 収録物識別子 |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0022-3484 |
| 収録物識別子 |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00704381 |
| 開始ページ |
|
|
開始ページ |
572 |
| 書誌情報 |
Journal of Periodontal Research
Journal of Periodontal Research
巻 42,
号 6,
p. 572-579,
発行日 2007-12
|
| 旧ID |
21458 |
JPR_42_572.pdf (361.3 KB)
