| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Absence of viral interference and different susceptibility to interferon between hepatitis B virus and hepatitis C virus in human hepatocyte chimeric mice |
|
言語 |
en |
| 作成者 |
Hiraga, Nobuhiko
Imamura, Michio
Hatakeyama, Tsuyoshi
Kitamura, Shosuke
Mitsui, Fukiko
Tanaka, Shinji
Tsuge, Masataka
Takahashi, Shoichi
Abe, Hiromi
Maekawa, Toshiro
Ochi, Hidenori
Tateno, Chise
Yoshizato, Katsutoshi
Wakita, Takaji
Chayama, Kazuaki
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2009 European Association for the Study of the Liver. Published by Elsevier B.V. |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Superinfection |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
JFH-1 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
IFN-stimulated genes |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Background/Aims: Both hepatitis B virus (HBV) and hepatitis C virus (HCV) replicate in the liver and show resistance against innate immunity and interferon (IFN) treatment. Whether there is interference between these two viruses is still controversial. We investigated the interference between these two viruses and the mode of resistance against IFN. Methods: We performed infection experiments with either or both of the two hepatitis viruses in human hepatocyte chimeric mice. Huh7 cell lines with stable production of HBV were also established and transfected with HCV JFH1 clone. Mice and cell lines were treated with IFN. The viral levels in mice sera and culture supernatants and messenger RNA levels of IFN-stimulated genes were measured. Results: No apparent interference between the two viruses was seen ill vivo. Only a small (0.3 log) reduction in serum HBV and a rapid reduction in HCV were observed after IFN treatment, regardless of infection with the other virus. In ill vitro studies, no interference between the two viruses was observed. The effect of IFN on each virus was not affected by the presence of the other virus. IFN-induced reductions of viruses in culture supernatants were similar to those in ill vivo study. Conclusions: No interference between the two hepatitis viruses exists in the liver in the absence of hepatitis. The mechanisms of IFN resistance of the two viruses target different areas of the IFN system. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Elsevier Science Bv |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.jhep.2009.09.002 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1016/j.jhep.2009.09.002 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0168-8278 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10459105 |
| 開始ページ |
|
|
開始ページ |
1046 |
| 書誌情報 |
Journal of Hepatology
Journal of Hepatology
巻 51,
号 6,
p. 1046-1054,
発行日 2009-12
|
| 旧ID |
29245 |
JHepatol_51_1046.pdf (156.3 KB)
