| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Deletion of angiotensin II type I receptor reduces hepatic steatosis |
|
言語 |
en |
| 作成者 |
Nabeshima, Yoshitaka
Tazuma, Susumu
Kanno, Keishi
Hyogo, Hideyuki
Chayama, Kazuaki
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2009 European Association for the Study of the Liver Published by Elsevier Ireland Ltd. |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Lipid metabolism |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Renin-angiotensin system |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Non-alcoholic fatty liver disease |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Non-alcoholic steatohepatitis |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Peroxisome proliferator-activated receptor alpha |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Background/Aims: A distinct subgroup of angiotensin II type I receptor (AT1R) blockers (ARBs) have been reported to suppress the development of hepatic steatosis. These effects were generally explained by selective peroxisome proliferator-activated receptor (PPAR) gamma modulating properties of ARBs, independent of their AT1R blocking actions. Here, we provide genetic evidence of the direct role for AT1R in hepatic steatosis. Methods: The effect of AT1R deletion on steatohepatitis was investigated in AT1a(-/-) mice. Furthermore, the influence of AT1R inhibition by telmisartan as well as gene silencing of AT1R by siRNA was assessed in an in vitro experiment using HepG2 cells. Results: Compared to wild-type (WT), A T1a(-/-) mice fed methionine-choline deficient (MCD) diet resulted in negligible lipid accumulation in the liver with marked induction of PPAR alpha mRNA. In vitro experiments also demonstrated reduced cellular lipid accumulation by telmisartan and AT1R knockdown following exposure of long chain fatty acids. This is pre-sumably explained by the observation that the expression of PPAR alpha and its target genes were significantly up-regulated in specific siRNA treated HepG2 cells. Conclusions: Our data indicate, in addition to pharmacological effect of ARBs on PPAR gamma activation, a key biological role for AT1R in the regulation of hepatic lipid metabolism. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Elsevier Science Bv |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.jhep.2009.01.018 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1016/j.jhep.2009.01.018 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0168-8278 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10459105 |
| 開始ページ |
|
|
開始ページ |
1226 |
| 書誌情報 |
Journal of Hepatology
Journal of Hepatology
巻 50,
号 6,
p. 1226-1235,
発行日 2009
|
| 旧ID |
27774 |
JHepatol_50_1226.pdf (415.7 KB)
