{"created":"2025-02-21T03:48:06.624937+00:00","id":2007310,"links":{},"metadata":{"_buckets":{"deposit":"8b109dd6-d105-4d70-975b-76584547e523"},"_deposit":{"created_by":41,"id":"2007310","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2007310"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02007310","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Influence of chlorine dioxide on cell death and cell cycle of human gingival fibroblasts","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nishikiori, Ryo","creatorNameLang":"en"}],"familyNames":[{"familyName":"Nishikiori","familyNameLang":"en"}],"givenNames":[{"givenName":"Ryo","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nomura, Yuji","creatorNameLang":"en"}],"familyNames":[{"familyName":"Nomura","familyNameLang":"en"}],"givenNames":[{"givenName":"Yuji","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sawajiri, Masahiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"Sawajiri","familyNameLang":"en"}],"givenNames":[{"givenName":"Masahiko","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Masuki, Kohei","creatorNameLang":"en"}],"familyNames":[{"familyName":"Masuki","familyNameLang":"en"}],"givenNames":[{"givenName":"Kohei","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hirata, Isao","creatorNameLang":"en"}],"familyNames":[{"familyName":"Hirata","familyNameLang":"en"}],"givenNames":[{"givenName":"Isao","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Okazaki, Masayuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Okazaki","familyNameLang":"en"}],"givenNames":[{"givenName":"Masayuki","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2008 Elsevier Ltd"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"apoptotic influence","subitem_subject_scheme":"Other"},{"subitem_subject":"dental disinfectants","subitem_subject_scheme":"Other"},{"subitem_subject":"chlorine dioxide","subitem_subject_scheme":"Other"},{"subitem_subject":"human gingival fibroblast","subitem_subject_scheme":"Other"},{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Objectives: The effects of chlorine dioxide (ClO2), sodium hypochlorite (NaOCl), and hydrogen peroxide (H2O2) on cell death and the cell cycle of human gingival fibroblast (HGF) cells were examined.    Methods: The inhibition of HGF cell growth was evaluated using a Cell Counting Kit-8. The cell cycle was assessed with propidium iodide-stained cells (distribution of cells in G0/G1, S, G2/M phases) using flow cytometry. The patterns of cell death (necrosis and apoptosis) were analyzed using flow cytometry with annexin V-FITC/PI staining.    Results: The lethal doses for 50% of the cells (LD50) of ClO2, NaOCl, and H2O2 were 0.16 mM, 0.79 mM, and 0.11 mM, respectively. All three dental disinfectants induced G0/G1 cell cycle arrest. H2O2 induced apoptosis at concentrations of 0.05 and 0.1 mM, while NaOCl and ClO2 did not induce significant apoptosis at any concentration examined.    Conclusions: These results suggest that ClO2 is sufficient for use as a dental disinfectant compared with H2O2 or NaOCl.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Elsevier Science Ltd."}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0300-5712","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00696556","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"993"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"998","bibliographicPageStart":"993","bibliographicVolumeNumber":"36","bibliographic_titles":[{"bibliographic_title":"Journal of Dentistry"},{"bibliographic_title":"Journal of Dentistry"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_b1a7d7d4d402bcce","subitem_version_type":"AO"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.jdent.2008.08.006","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1016/j.jdent.2008.08.006","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"JDent_36_993.pdf","filesize":[{"value":"281.7 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2007310/files/JDent_36_993.pdf"},"version_id":"d5b7a347-a419-4a12-8e38-ab338a9ad9f8"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"25929"},"item_title":"Influence of chlorine dioxide on cell death and cell cycle of human gingival fibroblasts","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2007310","relation_version_is_last":true,"title":["Influence of chlorine dioxide on cell death and cell cycle of human gingival fibroblasts"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-21T09:39:55.197592+00:00"}