{"created":"2025-02-21T03:42:27.393291+00:00","id":2007137,"links":{},"metadata":{"_buckets":{"deposit":"a0ee199f-03c7-4d78-83d0-8e8518ddcf44"},"_deposit":{"created_by":41,"id":"2007137","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2007137"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02007137","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"PD1 gene polymorphism is associated with a poor prognosis in hepatocellular carcinoma following liver resection, cohort study","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamamoto, Masateru","creatorNameLang":"en"}],"familyNames":[{"familyName":"Yamamoto","familyNameLang":"en"}],"givenNames":[{"givenName":"Masateru","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kobayashi, Tsuyoshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kobayashi","familyNameLang":"en"}],"givenNames":[{"givenName":"Tsuyoshi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Mashima, Hiroaki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Mashima","familyNameLang":"en"}],"givenNames":[{"givenName":"Hiroaki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Miki, Daiki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Miki","familyNameLang":"en"}],"givenNames":[{"givenName":"Daiki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kuroda, Shintaro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kuroda","familyNameLang":"en"}],"givenNames":[{"givenName":"Shintaro","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hamaoka, Michinori","creatorNameLang":"en"}],"familyNames":[{"familyName":"Hamaoka","familyNameLang":"en"}],"givenNames":[{"givenName":"Michinori","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Aikata, Hiroshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Aikata","familyNameLang":"en"}],"givenNames":[{"givenName":"Hiroshi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Chayama, Kazuaki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Chayama","familyNameLang":"en"}],"givenNames":[{"givenName":"Kazuaki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ohdan, Hideki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Ohdan","familyNameLang":"en"}],"givenNames":[{"givenName":"Hideki","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/"},{"subitem_rights":"This is not the published version. Please cite only the published version. この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Extrahepatic recurrence","subitem_subject_scheme":"Other"},{"subitem_subject":"Hepatocellular carcinoma","subitem_subject_scheme":"Other"},{"subitem_subject":"Liver resection","subitem_subject_scheme":"Other"},{"subitem_subject":"Programmed cell death protein-1","subitem_subject_scheme":"Other"},{"subitem_subject":"Single nucleotide polymorphism","subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Background  This study examined whether single nucleotide polymorphism (SNP) in programmed cell death protein (PD)-1 is related to the postoperative prognosis of patients with hepatocellular carcinoma (HCC). The immune checkpoint protein PD-1 is an important inhibitor of T cell responses. SNP in the promoter region of PD-1 -606 G/A has been reported to result in high activation and expression of PD-1 associated with cancer risk.    Materials and methods  We analyzed 321 patients with HCC who underwent hepatectomy between 2010 and 2015. PD-1 SNP was analyzed by polymerase chain reaction, and the prognosis after surgical treatment of patients with HCC was analyzed.    Results  The PD-1 SNP statuses were as follows: 90 AA (28.1%), 163 GA (50.8%), 68 GG (21.2%). The baseline parameters did not statistically differ between the three groups. The overall survival (OS) of patients with the GG genotype was significantly lower than that of those with the other genotypes (P = 0.031). The GG genotype was an independent risk factor for OS (P = 0.009; HR 2.201). There was no significant difference between the GG genotype and other genotypes in recurrent-free survival. The extrahepatic recurrence (EHR) rate of those with the GG genotype was significantly higher than that of those with the other genotypes (P = 0.036). The GG genotype was an independent risk factor for EHR (P = 0.008; HR 2.037).    Conclusions  The PD-1 SNP GG genotype is associated with poor survival and increased EHR in HCC. Furthermore, the GG genotype is an independent predictive factor for OS and EHR.","subitem_description_language":"en"},{"subitem_description":"This research was supported by AMED under Grant Number JP18fk0210007h0003 and by JSPS KAKENHI Grant Number JP 18K08706.","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"1743-9191","subitem_source_identifier_type":"ISSN"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"84"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-08","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"90","bibliographicPageStart":"84","bibliographicVolumeNumber":"80","bibliographic_titles":[{"bibliographic_title":"International Journal of Surgery"},{"bibliographic_title":"International Journal of Surgery"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_b1a7d7d4d402bcce","subitem_version_type":"AO"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.ijsu.2020.05.007","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.ijsu.2020.05.007","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"IntJSurg_80_84.pdf","filesize":[{"value":"573.8 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2007137/files/IntJSurg_80_84.pdf"},"version_id":"34b2322a-d368-4281-9cf3-09c0560a8282"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"51517"},"item_title":"PD1 gene polymorphism is associated with a poor prognosis in hepatocellular carcinoma following liver resection, cohort study","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2007137","relation_version_is_last":true,"title":["PD1 gene polymorphism is associated with a poor prognosis in hepatocellular carcinoma following liver resection, cohort study"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-21T09:10:54.929722+00:00"}