| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Role of NF-kB RelB in Aryl Hydrocarbon Receptor-Mediated Ligand Specific Effects |
|
言語 |
en |
| 作成者 |
Ishihara, Yasuhiro
Kado, Sarah Y.
Hoeper, Christiane
Harel, Shelly
Vogel, Christoph F. A.
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
AhR |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
cytokines |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
DC |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
IDO |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
NF-κB RelB |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
TCDD |
| 内容記述 |
|
|
内容記述 |
Here, we investigate the role of RelB in the regulation of genes which were identified to be induced in an aryl hydrocarbon receptor (AhR)-dependent manner and critically involved in regulation of immune responses. We analyzed the expression of genes of the AhR gene battery, cytokines, and immune regulatory enzymes in bone marrow-derived macrophages (BMM) and thymus of B6 wildtype (wt) mice and RelB knockout (RelB−/−) mice after treatment with various AhR ligands. The 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced expression of indoleamine 2,3-dioxygenase 1 (IDO1) and IDO2 was significantly repressed in thymus of RelB−/− mice but not in BMM derived from RelB−/− mice. Interestingly, the induced and basal expression of the cytokines interleukin (IL)-17A, IL-22, and CCL20 required the functional expression of RelB. The RelB-dependent expression of CCL20 was induced by the AhR ligands TCDD and 6-formylindolo[3,2-b]carbazole (FICZ), whereas indole-3-carbinol (I3C) suppressed CCL20 in lipopolysaccharide (LPS)-activated wt BMM. The LPS-induced expression of IL-6 and IL-10 was enhanced by TCDD and FICZ, whereas I3C significantly suppressed these cytokines in BMM. The exposure to FICZ led to higher increases of IL-17A and IL-22 mRNA compared to the effect of TCDD or I3C in thymus of wt mice. On the other hand, TCDD was the strongest inducer of CYP1A1, AhR Repressor (AhRR), and IDO2. In summary, these findings provide evidence for the important role of RelB in the transcriptional regulation of cytokines and enzymes induced by AhR ligands. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
This publication was supported by the National Institute of Environmental Health Sciences of the National Institutes of Health under award numbers R01ES029126 and R21ES030419 and by the University of California Davis Cancer Center support grant P30 CA093373. |
| 出版者 |
|
|
出版者 |
MDPI |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.3390/ijms20112652 |
| 関連情報 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
31151139 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3390/ijms20112652 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1661-6596 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1422-0067 |
| 開始ページ |
|
|
開始ページ |
2652 |
| 書誌情報 |
International Journal of Molecular Sciences
International Journal of Molecular Sciences
巻 20,
号 11,
p. 2652,
発行日 2019-05-30
|
| 旧ID |
48679 |
IntJMolSci_20_2652.pdf (892.8 KB)
