{"created":"2025-02-21T03:41:53.326914+00:00","id":2007118,"links":{},"metadata":{"_buckets":{"deposit":"e0308743-ce5c-41d8-94ea-d7bc8d1b8c45"},"_deposit":{"created_by":41,"id":"2007118","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2007118"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02007118","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Titanium Immobilized with an Antimicrobial Peptide Derived from Histatin Accelerates the Differentiation of Osteoblastic Cell Line, MC3T3-E1","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Makihira, Seicho","creatorNameLang":"en"}],"familyNames":[{"familyName":"Makihira","familyNameLang":"en"}],"givenNames":[{"givenName":"Seicho","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Shuto, Takahiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Shuto","familyNameLang":"en"}],"givenNames":[{"givenName":"Takahiro","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nikawa, Hiroki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Nikawa","familyNameLang":"en"}],"givenNames":[{"givenName":"Hiroki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Okamoto, Keishi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Okamoto","familyNameLang":"en"}],"givenNames":[{"givenName":"Keishi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Mine, Yuichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Mine","familyNameLang":"en"}],"givenNames":[{"givenName":"Yuichi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Takamoto, Yuko","creatorNameLang":"en"}],"familyNames":[{"familyName":"Takamoto","familyNameLang":"en"}],"givenNames":[{"givenName":"Yuko","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ohara, Masaru","creatorNameLang":"en"}],"familyNames":[{"familyName":"Ohara","familyNameLang":"en"}],"givenNames":[{"givenName":"Masaru","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tsuji, Koichiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Tsuji","familyNameLang":"en"}],"givenNames":[{"givenName":"Koichiro","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland."}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"antimicrobial peptide","subitem_subject_scheme":"Other"},{"subitem_subject":"titanium surface","subitem_subject_scheme":"Other"},{"subitem_subject":"MC3T3-E1 cells","subitem_subject_scheme":"Other"},{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"The objective of this study was to evaluate the effect of titanium immobilized with a cationic antimicrobial peptide (JH8194) derived from histatin on the biofilm formation of Porphyromonas gingivalis and differentiation of osteoblastic cells (MC3T3-E1). The titanium specimens (Ti) were immobilized with JH8194, according to the method previously described. The colonization of P. gingivalis on JH8194-Ti was significantly lower than that on control- and blocking-Ti. JH8194-Ti enhanced the mRNA expressions of Runx2 and OPN, and ALPase activity in the MC3T3-E1, as compared with those of control- and blocking-Ti. These results, taken together, suggested the possibility that JH8194-Ti may be a potential aid to shorten the period of acquiring osseointegration.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Molecular Diversity Preservation International-MDPI"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"1422-0067","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA12038549","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"1458"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-04-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"1470","bibliographicPageStart":"1458","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"International Journal of Molecular Sciences"},{"bibliographic_title":"International Journal of Molecular Sciences"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3390/ijms11041458","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.3390/ijms11041458","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"IntJMolSci_11_1458.pdf","filesize":[{"value":"379.9 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2007118/files/IntJMolSci_11_1458.pdf"},"version_id":"02a1a7a0-fa38-4c62-8be4-5f815af695a0"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"30399"},"item_title":"Titanium Immobilized with an Antimicrobial Peptide Derived from Histatin Accelerates the Differentiation of Osteoblastic Cell Line, MC3T3-E1","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2007118","relation_version_is_last":true,"title":["Titanium Immobilized with an Antimicrobial Peptide Derived from Histatin Accelerates the Differentiation of Osteoblastic Cell Line, MC3T3-E1"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-21T09:09:06.806128+00:00"}