| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Inhibitory effects of vitamin K3 on DNA polymerase and angiogenesis |
|
言語 |
en |
| 作成者 |
Matsubara, Kiminori
Kayashima, Tomoko
Mori, Masaharu
Yoshida, Hiromi
Mizushina, Yoshiyuki
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2008 Spandidos Publications UK Ltd. |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
angiogenesis |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
aortic ring |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
endothelial cells |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
vitamin K3 |
| 内容記述 |
|
|
内容記述 |
Vitamins play essential roles in cellular reactions and maintain human health. Recent studies have revealed that some vitamins including D3, B6 and K2 and their derivatives have an anti-cancer effect. As a mechanism, their inhibitory effect on cancer-related angiogenesis has been demonstrated. Vitamin K2 (menaquinones) has an anti-cancer effect in particular for hepatic cancer and inhibits angiogenesis. In the current study, we demonstrated that sole vitamin K3 (menadione) selectively inhibits the in vitro activity of eukaryotic DNA polymerase γ, which is a mitochondrial DNA polymerase, and suppresses angiogenesis in a rat aortic ring model. The anti-angiogenic effect of vitamin K3 has been shown in angiogenesis models using human umbilical vein endothelial cells (HUVECs) with regard to HUVEC growth, tube formation on reconstituted basement membrane and chemotaxis. These results suggest that vitamin K3 may be a potential anti-cancer agent like vitamin K2. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
This work was supported by the ‘Academic Frontier’ Project for Private Universities (Kobe-Gakuin University), matching fund subsidy from MEXT, 2006-2010, (K.M., H.Y. and Y.M.) and in part by a grant from the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT). K.M. acknowledges a Grant-in-Aid for Young Scientists (B) (No. 18700608) from MEXT. Y.M. also acknowledges a Grant-in-Aid for Young Scientists (A) (No. 19680031) from MEXT, and Grants-in-Aid from the Nakashima Foundation and the Foundation of Oil & Fat Industry, Kaikan, Japan. |
| 出版者 |
|
|
出版者 |
Spandidos Publications |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
|
|
関連名称 |
Matsubara, K., Kayashima, T., Mori, M., Yoshida, H., Mizushina, Y. "Inhibitory effects of vitamin K3 on DNA polymerase and angiogenesis". International Journal of Molecular Medicine 22, no. 3 (2008): 381-387. |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.3892/ijmm_00000034 |
| 関連情報 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
18698499 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.3892/ijmm_00000034 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1107-3756 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1791-244X |
| 開始ページ |
|
|
開始ページ |
381 |
| 書誌情報 |
International Journal of Molecular Medicine
International Journal of Molecular Medicine
巻 22,
号 3,
p. 381-387,
発行日 2008-09
|
| 旧ID |
48181 |
IJMM_22_381.pdf (177.2 KB)
