| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Genetic ablation of the Bach1 gene reduces hyperoxic lung injury in mice: Role of IL-6 |
|
言語 |
en |
| 作成者 |
Tanimoto, Takuya
Hattori, Noboru
Senoo, Tadashi
Furonaka, Makoto
Ishikawa, Nobuhisa
Fujitaka, Kazunori
Haruta, Yoshinori
Yokoyama, Akihito
Igarashi, Kazuhiko
Kohno, Nobuoki
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2009 Elsevier Inc. |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Bach1 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Heme oxygenase-1 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Hyperoxic lung injury |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
IL-6 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Oxidative stress |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Survival |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Bronchoalveolar lavage |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Small interfering RNA |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Chromatin immunoprecipitation analysis |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Free radicals |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Bach1 is a transcriptional repressor of the heme oxygenase (HO)-1 gene. Bach1-null (Bach1(-/-)) mice are reported to be protected from myocardial ischemia/reperfusion injury; however, the effect of Bach1 disruption on another oxidative stress model of hyperoxic lung injury has yet to be determined. To investigate the role of Bach1 in hyperoxic lung injury, Bach1(-/-) mice and wild-type (WT) mice were exposed to 90% O-2. During hyperoxic exposure, the survival of Bach1(-/-) mice was significantly longer than that of WT mice. However, the administration of zinc protoporphyrin, an inhibitor of HO-1 activity, did not change the mortality in either of the mice. thus suggesting that this protective effect was not mediated by an HO-1 overexpression in Bach1(-/-) mice. The indices of lung injury in the lungs of Bach1(-/-) mice were lower than those of WT mice; unexpectedly, however, the levels of IL-6 in bronchoalveolar lavage (BAL) fluid from Bach1(-/-) mice were significantly higher than those of WT mice. Interestingly, the intrapulmonary administration of small interfering RNA against IL-6 was shown to reduce the IL-6 levels in BAL fluids and shorten the survival in Bach1(-/-) mice during hyperoxic exposure. In addition, a chromatin immunoprecipitation analysis revealed the binding of Bach1 to the IL-6 promoter and its detachment after oxidative stress. Considering the previous observation that the transgenic mice overexpressing IL-6 are protected from hyperoxic lung injury, these results therefore indicate that IL-6 mediates an increased survival in Bach1(-/-) mice during hyperoxic exposure. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Elsevier Science Inc |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.freeradbiomed.2009.01.017 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1016/j.freeradbiomed.2009.01.017 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0891-5849 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA10678845 |
| 開始ページ |
|
|
開始ページ |
1119 |
| 書誌情報 |
Free Radical Biology and Medicine
Free Radical Biology and Medicine
巻 46,
号 8,
p. 1119-1126,
発行日 2009
|
| 旧ID |
27697 |
FreeRadBioMed_46_1119.pdf (2.3 MB)
