{"created":"2025-02-21T03:33:50.250880+00:00","id":2006850,"links":{},"metadata":{"_buckets":{"deposit":"d7bee608-f2f5-4b0e-8449-92fb18082ab3"},"_deposit":{"created_by":41,"id":"2006850","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2006850"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02006850","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Inhibitory effect of 4-(2-aminoethyl)-benzenesulfonyl fluoride, a serine protease inhibitor, on PI3K inhibitor-induced CHOP expression","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hosoi, Toru","creatorNameLang":"en"}],"familyNames":[{"familyName":"Hosoi","familyNameLang":"en"}],"givenNames":[{"givenName":"Toru","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hyoda, Kanae","creatorNameLang":"en"}],"familyNames":[{"familyName":"Hyoda","familyNameLang":"en"}],"givenNames":[{"givenName":"Kanae","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Okuma, Yasunobu","creatorNameLang":"en"}],"familyNames":[{"familyName":"Okuma","familyNameLang":"en"}],"givenNames":[{"givenName":"Yasunobu","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nomura, Yasuyuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Nomura","familyNameLang":"en"}],"givenNames":[{"givenName":"Yasuyuki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ozawa, Koichiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Ozawa","familyNameLang":"en"}],"givenNames":[{"givenName":"Koichiro","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2007 Elsevier Ltd."}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"4-(2-aminoethyl)-benzenesulfonyl fluoride (AEBSF)","subitem_subject_scheme":"Other"},{"subitem_subject":"phosphatidylinositol 3-kinase (PI3K)","subitem_subject_scheme":"Other"},{"subitem_subject":"CHOP","subitem_subject_scheme":"Other"},{"subitem_subject":"endoplasmic reticulum stress","subitem_subject_scheme":"Other"},{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Endoplasmic reticulum stress contributes to several diseases such as neurodegenerative disorders and diabetes. In the previous report, we found that phosphatidylinositol 3-kinase (PI3K) down-regulation is important for inducing CHOP expression, an endoplasmic reticulum stress-induced transcription factor. In the present study, we investigated the effect of 4-(2-aminoethyl)-benzenesulfonyl fluoride (AEBSF), a serine protease inhibitor, on PI3K inhibitor-induced CHOP expression. We found that AEBSF completely inhibited PI3K inhibitor-induced CHOP expression at both mRNA and protein levels. It is suggested that AEBSF is an important drug from a pharmacological point of view and the results may have important implications for understanding endoplasmic reticulum stress-related diseases.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0014-2999","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00639687","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"8"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-01-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"11","bibliographicPageStart":"8","bibliographicVolumeNumber":"554","bibliographic_titles":[{"bibliographic_title":"European Journal of Pharmacology"},{"bibliographic_title":"European Journal of Pharmacology"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_b1a7d7d4d402bcce","subitem_version_type":"AO"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.ejphar.2006.09.063","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"17109853","subitem_relation_type_select":"PMID"}},{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1016/j.ejphar.2006.09.063","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"EuroJPharm_554_8.pdf","filesize":[{"value":"2.5 MB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2006850/files/EuroJPharm_554_8.pdf"},"version_id":"6c6b48e0-8c38-434d-aeca-1dfd4a8fc757"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"17065"},"item_title":"Inhibitory effect of 4-(2-aminoethyl)-benzenesulfonyl fluoride, a serine protease inhibitor, on PI3K inhibitor-induced CHOP expression","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2006850","relation_version_is_last":true,"title":["Inhibitory effect of 4-(2-aminoethyl)-benzenesulfonyl fluoride, a serine protease inhibitor, on PI3K inhibitor-induced CHOP expression"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-21T08:33:15.866017+00:00"}