{"created":"2025-02-21T03:31:13.912017+00:00","id":2006761,"links":{},"metadata":{"_buckets":{"deposit":"5ae33684-edbc-4326-b1e5-0d1e256d5a0a"},"_deposit":{"created_by":41,"id":"2006761","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2006761"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02006761","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Bacteriophage control of Pseudomonas plecoglossicida infection in ayu.","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Park, Se Chang","creatorNameLang":"en"}],"familyNames":[{"familyName":"Park","familyNameLang":"en"}],"givenNames":[{"givenName":"Se Chang","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nakai, Toshihiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Nakai","familyNameLang":"en"}],"givenNames":[{"givenName":"Toshihiro","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2003 Inter-Research."}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Bacteriophage","subitem_subject_scheme":"Other"},{"subitem_subject":"Phage therapy","subitem_subject_scheme":"Other"},{"subitem_subject":"Fish disease","subitem_subject_scheme":"Other"},{"subitem_subject":"Biological control","subitem_subject_scheme":"Other"},{"subitem_subject":"Pseudomonas plecoglossicida","subitem_subject_scheme":"Other"},{"subitem_subject":"Plecoglossus altivelis","subitem_subject_scheme":"Other"},{"subitem_subject":"480","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Two previously isolated phages were used to examine the therapeutic effects against Pseudomonas plecoglossicida infection in ayu Plecoglossus altivelis. Phage PPp-W4 (Podoviridae) inhibited the in vitro growth of P. plecoglossicida more effectively than Phage PPpW-3 (Myoviridae), and a mixture (PPpW-3/W-4) of the 2 phages exhibited the highest inhibitory activity. In phage therapy experiments, ayu were fed P. plecoglossicida-impregnated feed (107 CFU fish-1) and then fed phage-impregnated feed (107 PFU fish-1). Mortalities of fish receiving PPpW-3, PPpW-4, PPpW-3/W-4, and a control fish receiving no phages were 53.3, 40.0, 20.0 and 93.3%, respectively. Phage (PPpW-3/W-4)-receiving fish also showed high protection against water-borne infection with P. plecoglossicida. In a field trial, when phage (PPpW-3/W-4)-impregnated feed was administered to ayu in a pond where the disease occurred naturally, daily mortality of fish decreased at a constant level (5% d-1) to one-third after a 2 wk period. The causal relationship of phages in this phenomenon was verified by the long-lasting appearance of administered phages in the kidneys of the fish, and a disappearance of P. plecoglossicida from apparently healthy fish. Neither phage-resistant organisms nor phage-neutralizing antibodies were detected in diseased fish or apparently healthy fish, respectively. These results indicate the potential for phage control of the disease.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Inter-Research"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0177-5103","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"1616-1580","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA10443976","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"33"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-01-22","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"39","bibliographicPageStart":"33","bibliographicVolumeNumber":"53","bibliographic_titles":[{"bibliographic_title":"Diseases of Aquatic Organisms"},{"bibliographic_title":"Diseases of Aquatic Organisms"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3354/dao053033","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.3354/dao053033","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"dao053p033.pdf","filesize":[{"value":"182.6 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2006761/files/dao053p033.pdf"},"version_id":"5a19390b-58d6-436f-9312-b68e6cdd8c73"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"25662"},"item_title":"Bacteriophage control of Pseudomonas plecoglossicida infection in ayu.","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2006761","relation_version_is_last":true,"title":["Bacteriophage control of Pseudomonas plecoglossicida infection in ayu."],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-21T08:21:11.211378+00:00"}