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Expression of matrix metalloproteinase genes in regressing or remodeling organs during the amphibian metamorphosis
https://hiroshima.repo.nii.ac.jp/records/2006736
https://hiroshima.repo.nii.ac.jp/records/2006736d580834e-719b-45ca-b7b9-f9291a6c56c7
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
DevGrowthDiffer_49-2_131.pdf (1.4 MB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Expression of matrix metalloproteinase genes in regressing or remodeling organs during the amphibian metamorphosis | |||||||||||
| 言語 | en | |||||||||||
| 作成者 |
Fujimoto, Kenta
× Fujimoto, Kenta
× Nakajima, Keisuke
× Yaoita, Yoshio
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| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
| 権利情報 | ||||||||||||
| 権利情報 | Copyright (c) 2007 Blackwell Publishing. The definitive version is available at www.blackwell-synergy.com | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | amphibian metamorphosis | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | aatrix metalloproteinases | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | thyroid hormone response element | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | thyroid hormone | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | xenopus | |||||||||||
| 主題 | ||||||||||||
| 主題Scheme | NDC | |||||||||||
| 主題 | 460 | |||||||||||
| 内容記述 | ||||||||||||
| 内容記述 | Several matrix metalloproteinases (MMP) are induced by thyroid hormone (TH) during the climax of amphibian metamorphosis, and play a pivotal role in the remodeling intestine and the regressing tail and gills by degrading the extracellular matrix (ECM). We compared MMP gene expression levels precisely by the quantitative real time reverse transcription-polymerase chain reaction. The expression of MMP genes increases prominently at NF stages 60, 60-61, and 62 in the intestine, gills, and tail, respectively, when the drastic morphological change starts in each organ. The gene expression analysis in the TH-treated tadpoles and cell line revealed that MMP mRNAs are up-regulated in response to TH quickly within several hours to low levels and then increase in a day to high levels. All TH-induced MMP genes have thyroid hormone response elements (TREs). The presence of high affinity TREs in MMP genes correlates with the early TH-induction. Based on these results, we propose that TH stimulates the transcription of MMP genes through TREs within several hours to low levels, and then bring about the main increase of mRNAs by TH-induced transcriptional factors including TH receptor β in cell type-specific transcriptional environment. | |||||||||||
| 言語 | en | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | Blackwell Publishing | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | AO | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_b1a7d7d4d402bcce | |||||||||||
| 関連情報 | ||||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | 10.1111/j.1440-169X.2007.00916.x | |||||||||||
| 関連情報 | ||||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | http://dx.doi.org/10.1111/j.1440-169X.2007.00916.x | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||
| 収録物識別子 | 0012-1592 | |||||||||||
| 収録物識別子 | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA00627804 | |||||||||||
| 開始ページ | ||||||||||||
| 開始ページ | 131 | |||||||||||
| 書誌情報 |
Development, Growth & Differentiation Development, Growth & Differentiation 巻 49, 号 2, p. 131-143, 発行日 2007-02 |
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| 旧ID | 20659 | |||||||||||
