| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Impact of Platelet Reactivity to Adenosine Diphosphate Before Implantation of Drug-Eluting Stents on Subsequent Adverse Cardiac Events in Patients With Stable Angina |
|
言語 |
en |
| 作成者 |
Motoda, Chikaaki
Ueda, Hironori
Hayashi, Yasuhiko
Toyofuku, Mamoru
Okimoto, Tomokazu
Otsuka, Masaya
Tamekiyo, Hiromichi
Kawase, Tomoharu
Kihara, Yasuki
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
(c) All rights are reserved to the Japanese Circulation Society. |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Anti-platelet therapy |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Drug-eluting stent |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Percutaneous coronary intervention |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Platelet reactivity to ADP |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Revascularization |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Background: Diverse pharmacological effects of anti-platelet thienopyridines due to individual differences in metabolism have been reported. However, an association between on-treatment platelet reactivity and adverse ischemic events after drug-eluting stent (DES) implantation in Japanese patients has not been fully elucidated. Methods and Results: A total of 450 consecutive patients on dual anti-platelet therapy (aspirin and ticlopidine) with stable angina who underwent DES implantation were enrolled. Adenosine diphosphate (ADP)-induced platelet aggregation was measured before DES implantation using the screen filtration pressure method. The ADP concentration necessary for 50% aggregation was designated as the platelet aggregation threshold index (PATI). A composite primary endpoint of cardiac death, myocardial infarction, target lesion revascularization (TLR), and stent thrombosis occurring within 1 year after stenting, was evaluated. A PATI value <4.8 mu mol/L was defined as high on-treatment reactivity to ADP. The composite primary endpoint occurred in 55 patients (12.2%) in the 1-year-period after DES implantation, and the prevalence was 19.0% and 5.1% in groups with high and low on-treatment reactivity to ADP, respectively, showing a significantly higher prevalence in the high reactivity group (P<0.001). The main event was TLR (18.1% vs. 5.1%, P<0.001). Conclusions: These data suggested that high on-treatment platelet reactivity to ADP and subsequent occurrence of adverse ischemic events (particularly TLR) were correlated in patients with stable angina who underwent DES implantation. (Circ J 2012; 76: 641-649) |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Japanese Circulation Society |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1253/circj.CJ-11-0435 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1253/circj.CJ-11-0435 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1346-9843 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11591968 |
| 開始ページ |
|
|
開始ページ |
641 |
| 書誌情報 |
Circulation Journal
Circulation Journal
巻 76,
号 3,
p. 641-649,
発行日 2012
|
| 旧ID |
34785 |
CJ_76_641.pdf (687.4 KB)
