| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
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|
タイトル |
The Butenolide Signaling Molecules SRB1 and SRB2 Induce Lankacidin and Lankamycin Production in Streptomyces rochei |
|
言語 |
en |
| タイトル |
|
|
タイトル |
Butenolide signaling molecules, SRB1 and SRB2, that induce lankacidin and lankamycin production in Streptomyces rochei |
|
言語 |
ja |
| 作成者 |
Arakawa, Kenji
Tsuda, Naoto
Taniguchi, Akihiro
KInashi, Haruyasu
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| アクセス権 |
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|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
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|
権利情報 |
Copyright © 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim |
| 権利情報 |
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|
権利情報 |
This is the peer reviewed version of the following article: CHEMBIOCHEM. 2012, July 9;13(10):1447-1457, which has been published in final form at https://doi.org/10.1002/cbic.201200149. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
| 権利情報 |
|
|
権利情報 |
This is not the published version. Please cite only the published version. この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。 |
| 主題 |
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|
主題Scheme |
Other |
|
主題 |
natural product |
| 主題 |
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|
主題Scheme |
Other |
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主題 |
antibiotics |
| 主題 |
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|
主題Scheme |
Other |
|
主題 |
Streptomyces |
| 主題 |
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|
主題Scheme |
Other |
|
主題 |
butenolides |
| 主題 |
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|
主題Scheme |
Other |
|
主題 |
signaling molecules |
| 内容記述 |
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内容記述 |
Novel signaling molecule(s) that induce lankacidin and lankamycin production in Streptomyces rochei were extracted from the culture filtrate and purified by Sephadex LH20 and silica gel chromatography with the help of bioassay. Chiral HPLC and ESI-MS analyses indicated the presence of two active components, SRB1 and SRB2, and their molecular formulae were established to be C15H24O5 and C16H26O5, respectively. Based on extensive NMR analysis, SRB1 and SRB2 were determined to be 2-(1’-hydroxyl-6’-oxo-8’-methylnonyl)-3-methyl-4-hydroxybut-2-en-1,4-olide and 2-(1’-hydroxyl-6’-oxo-8’-methyldecyl)-3-methyl-4-hydroxybut-2-en-1,4-olide, respectively. These structures were finally confirmed by chemical synthesis and the absolute configuration of C-1’ was determined to be R. The synthetic 1’R-isomers induced production of lankacidin and lankamycin at around 40 nM concentration. Thus, SRB1 and SRB2 are distinct from the well-known 2,3-disubstituted γ-butyrolactone molecules such as A-factor, virginia butanolide, and SCB1 and belong to the γ-butenolide family following avenolide which has been recently isolated from Streptomyces avermitilis. |
|
言語 |
en |
| 内容記述 |
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|
内容記述タイプ |
Other |
|
内容記述 |
アクセプト後にタイトル・アブストラクト等変更あり、著者最終稿は変更前のタイトル"Butenolide signaling molecules, SRB1 and SRB2, that induce lankacidin and lankamycin production in Streptomyces rochei" |
| 内容記述 |
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|
内容記述タイプ |
Other |
|
内容記述 |
This work was supported by a Grants‐in‐Aid for Scientific Research on Innovative Areas from the Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT), and a Noda Institute for Scientific Research Grant. |
| 内容記述 |
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|
内容記述タイプ |
Other |
|
内容記述 |
Supporting information for this article is available on the WWW underhttp://dx.doi.org/10.1002/cbic.201200149. |
| 出版者 |
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|
出版者 |
Wiley‐VCH Verlag |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
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識別子タイプ |
DOI |
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関連識別子 |
10.1002/cbic.201200149 |
| 関連情報 |
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識別子タイプ |
PMID |
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関連識別子 |
22761035 |
| 関連情報 |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1002/cbic.201200149 |
| 収録物識別子 |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1439-4227 |
| 収録物識別子 |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1439-7633 |
| 開始ページ |
|
|
開始ページ |
1447 |
| 書誌情報 |
CHEMBIOCHEM
CHEMBIOCHEM
巻 13,
号 10,
p. 1447-1457,
発行日 2012-07-09
|
| 旧ID |
48656 |
Chembiochem_13_1447.pdf (192.3 KB)
