{"created":"2025-02-21T03:23:39.104698+00:00","id":2006514,"links":{},"metadata":{"_buckets":{"deposit":"7cc93337-39f1-4d18-ac17-f148a1ec655e"},"_deposit":{"created_by":41,"id":"2006514","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2006514"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02006514","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Differences in serum SP-D levels between German and Japanese subjects are associated with SFTPD gene polymorphisms","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Horimasu, Yasushi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Horimasu","familyNameLang":"en"}],"givenNames":[{"givenName":"Yasushi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hattori, Noboru","creatorNameLang":"en"}],"familyNames":[{"familyName":"Hattori","familyNameLang":"en"}],"givenNames":[{"givenName":"Noboru","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ishikawa, Nobuhisa","creatorNameLang":"en"}],"familyNames":[{"familyName":"Ishikawa","familyNameLang":"en"}],"givenNames":[{"givenName":"Nobuhisa","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tanaka, Sonosuke","creatorNameLang":"en"}],"familyNames":[{"familyName":"Tanaka","familyNameLang":"en"}],"givenNames":[{"givenName":"Sonosuke","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Bonella, Francesco","creatorNameLang":"en"}],"familyNames":[{"familyName":"Bonella","familyNameLang":"en"}],"givenNames":[{"givenName":"Francesco","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ohshimo, Shinichiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Ohshimo","familyNameLang":"en"}],"givenNames":[{"givenName":"Shinichiro","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Guzman, Josune","creatorNameLang":"en"}],"familyNames":[{"familyName":"Guzman","familyNameLang":"en"}],"givenNames":[{"givenName":"Josune","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Costabel, Ulrich","creatorNameLang":"en"}],"familyNames":[{"familyName":"Costabel","familyNameLang":"en"}],"givenNames":[{"givenName":"Ulrich","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kohno, Nobuoki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kohno","familyNameLang":"en"}],"givenNames":[{"givenName":"Nobuoki","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2014 Horimasu et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited."}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Biological marker","subitem_subject_scheme":"Other"},{"subitem_subject":"Idiopathic interstitial pneumonia","subitem_subject_scheme":"Other"},{"subitem_subject":"Single nucleotide polymorphism","subitem_subject_scheme":"Other"},{"subitem_subject":"Surfactant protein-A (SP-A)","subitem_subject_scheme":"Other"},{"subitem_subject":"Surfactant protein-D (SP-D)","subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Background: Surfactant protein A (SP-A) and SP-D are clinically established in Japan as serum biomarkers for diagnosing interstitial lung diseases (ILDs). Serum SP-D levels are affected by genetic variants. We conducted the present study to examine whether serum SP-A and/or SP-D levels in healthy subjects (HS) and patients with ILDs differ between populations with different genetic backgrounds.  Methods: German subjects (n = 303; 138 patients with idiopathic interstitial pneumonias [IIPs] and 165 HS) and Japanese subjects (n = 369; 94 patients with IIPs and 275 HS) were enrolled. Serum SP-A and SP-D levels were measured using an enzyme-linked immunosorbent assay, and four single-nucleotide polymorphisms (SNPs) in the SFTPD gene were genotyped using genomic DNA extracted from blood samples.  Results: In both the German and Japanese cohorts, serum SP-A and SP-D levels were significantly higher in patients with IIPs than in HS. There were no significant differences in SP-A levels between the German and Japanese cohorts; however, we found that serum SP-D levels were significantly higher in the German cohort, both in patients with IIPs and in HS (p < 0.001 and p = 0.005, respectively). Furthermore, the genotype distributions of the four SNPs in the SFTPD gene (rs721917, rs1998374, rs2243639, and rs3088308) were significantly different between German and Japanese cohorts (p < 0.001, p <0.001, p =0.022, and p < 0.001, respectively), and univariate linear regression analyses revealed that the genotypes of rs721917, rs1998374, and rs2243639 significantly correlated with serum SP-D levels (p < 0.001, p < 0.001, and p = 0.011, respectively). Furthermore, multivariate analyses revealed that the genotypes of these three SNPs correlated independently with serum SP-D levels (p < 0.001, p = 0.001, and p = 0.038, respectively), whereas ethnicity did not significantly correlate with serum SP-D levels.  Conclusions: In patients with IIPs and HS, serum SP-D, but not SP-A, levels were significantly higher in the German than in the Japanese cohort, in part, because of the different frequencies of SFTPD gene polymorphisms.","subitem_description_language":"en"},{"subitem_description":"This work was supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan and Arbeitsgemeinschaft zur Förderung der Pneumologie an der Ruhrlandklinik (AFPR).","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"BMC"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"1471-2350","subitem_source_identifier_type":"ISSN"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"4"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-01-08","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4","bibliographicVolumeNumber":"15","bibliographic_titles":[{"bibliographic_title":"BMC Medical Genetics"},{"bibliographic_title":"BMC Medical Genetics"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/1471-2350-15-4","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"24400879","subitem_relation_type_select":"PMID"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1186/1471-2350-15-4","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"BMCMedGenet_15_4.pdf","filesize":[{"value":"590.9 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2006514/files/BMCMedGenet_15_4.pdf"},"version_id":"34089def-808e-4e52-af77-87ed1fc5fa4a"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"48661"},"item_title":"Differences in serum SP-D levels between German and Japanese subjects are associated with SFTPD gene polymorphisms","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2006514","relation_version_is_last":true,"title":["Differences in serum SP-D levels between German and Japanese subjects are associated with SFTPD gene polymorphisms"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-21T07:45:28.374567+00:00"}