{"created":"2025-02-21T03:23:28.509402+00:00","id":2006508,"links":{},"metadata":{"_buckets":{"deposit":"94036078-dc29-48d0-a114-0276f3875042"},"_deposit":{"created_by":41,"id":"2006508","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2006508"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02006508","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Associations of a PTPN11 G/A polymorphism at intron 3 with Helicobactor pylori seropositivity, gastric atrophy and gastric cancer in Japanese","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hishida, Asahi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Hishida","familyNameLang":"en"}],"givenNames":[{"givenName":"Asahi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Matsuo, Keitaro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Matsuo","familyNameLang":"en"}],"givenNames":[{"givenName":"Keitaro","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Goto, Yasuyuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Goto","familyNameLang":"en"}],"givenNames":[{"givenName":"Yasuyuki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Naito, Mariko","creatorNameLang":"en"}],"familyNames":[{"familyName":"Naito","familyNameLang":"en"}],"givenNames":[{"givenName":"Mariko","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Wakai, Kenji","creatorNameLang":"en"}],"familyNames":[{"familyName":"Wakai","familyNameLang":"en"}],"givenNames":[{"givenName":"Kenji","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tajima, Kazuo","creatorNameLang":"en"}],"familyNames":[{"familyName":"Tajima","familyNameLang":"en"}],"givenNames":[{"givenName":"Kazuo","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hamajima, Nobuyuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Hamajima","familyNameLang":"en"}],"givenNames":[{"givenName":"Nobuyuki","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© Hishida et al; licensee BioMed Central Ltd. 2009 . This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited."}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"[Background]: Previous studies have revealed the significance of Helicobacter pylori (H. pylori) infection as a risk factor of gastric cancer. Cytotoxin-associated gene A (cagA) positivity has been demonstrated to determine the clinical outcome of H. pylori infection in the presence of SHP-2 (src homology 2 domain-containing protein tyrosine phosphatase-2). This study aimed to examine the formerly reported association of G/A PTPN11 (protein-tyrosine phosphatase, nonreceptor-type 11) polymorphism (rs2301756) with gastric atrophy, as well as the association with gastric cancer in a Japanese population using a large sample size.  [Methods]: Study subjects were 583 histologically diagnosed patients with gastric cancer (429 males and 154 females) and age- and sex-frequency-matched 1,636 non-cancer outpatients (1,203 males and 433 females), who visited Aichi Cancer Center Hospital between 2001–2005. Serum anti-H. pylori IgG antibody and pepsinogens were measured to evaluate H. pylori infection and gastric atrophy, respectively. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by a logistic model.  [Results]: Among H. pylori seropositive non-cancer outpatients, the age- and sex-adjusted OR of gastric atrophy was 0.82 (95% CI 0.62–1.10, P = 0.194) for G/A, 0.84 (95% CI 0.39–1.81, P = 0.650) for A/A, and 0.83 (95% CI 0.62–1.09, P = 0.182) for G/A+A/A, relative to G/G genotype, and that of severe gastric atrophy was 0.70 (95% CI 0.47–1.04, P = 0.079), 0.56 (95% CI 0.17–1.91, P = 0.356), and 0.68 (95% CI 0.46–1.01, P = 0.057), respectively. Among H. pylori infected subjects (H. pylori seropositive subjects and seronegative subjects with gastric atrophy), the adjusted OR of severe gastric atrophy was further reduced; 0.62 (95% CI 0.42–0.90, P = 0.012) for G/A+A/A. The distribution of the genotype in patients with gastric cancer was not significantly different from that for H. pylori infected subjects without gastric atrophy.  [Conclusion]: Our study results revealed that those with the A/A genotype of PTPN11 rs2301756 polymorphism are at lower risk of severe gastric atrophy, but are not associated with a decreased risk of gastric cancer, which partially supported our previous finding that the polymorphism in the PTPN11 gene encoding SHP-2 was associated with the gastric atrophy risk in H. pylori infected Japanese. The biological roles of this PTPN11 polymorphism require further investigation.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"BioMed Central Ltd"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"1471-230X","subitem_source_identifier_type":"ISSN"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"51"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-07-09","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"51","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"BMC Gastroenterology"},{"bibliographic_title":"BMC Gastroenterology"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/1471-230X-9-51","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"19589142","subitem_relation_type_select":"PMID"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1186/1471-230X-9-51","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"bmcg_9_51.pdf","filesize":[{"value":"294.6 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2006508/files/bmcg_9_51.pdf"},"version_id":"54135762-2403-496d-807e-ffe1b715602c"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"47121"},"item_title":"Associations of a PTPN11 G/A polymorphism at intron 3 with Helicobactor pylori seropositivity, gastric atrophy and gastric cancer in Japanese","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2006508","relation_version_is_last":true,"title":["Associations of a PTPN11 G/A polymorphism at intron 3 with Helicobactor pylori seropositivity, gastric atrophy and gastric cancer in Japanese"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-21T07:44:44.549270+00:00"}