{"created":"2025-02-21T03:22:48.904684+00:00","id":2006485,"links":{},"metadata":{"_buckets":{"deposit":"9da2bca8-6fd8-4c2b-976b-9d1e438cea34"},"_deposit":{"created_by":41,"id":"2006485","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2006485"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02006485","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Characterization of CO3Ap-collagen sponges using X-ray high-resolution microtomography","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Itoh, Manabu","creatorNameLang":"en"}],"familyNames":[{"familyName":"Itoh","familyNameLang":"en"}],"givenNames":[{"givenName":"Manabu","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Shimazu, Atsushi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Shimazu","familyNameLang":"en"}],"givenNames":[{"givenName":"Atsushi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hirata, Isao","creatorNameLang":"en"}],"familyNames":[{"familyName":"Hirata","familyNameLang":"en"}],"givenNames":[{"givenName":"Isao","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yoshida, Yasuhiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"Yoshida","familyNameLang":"en"}],"givenNames":[{"givenName":"Yasuhiro","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Shintani, Hideaki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Shintani","familyNameLang":"en"}],"givenNames":[{"givenName":"Hideaki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Okazaki, Masayuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Okazaki","familyNameLang":"en"}],"givenNames":[{"givenName":"Masayuki","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2003 Elsevier Ltd."}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Bone repair","subitem_subject_scheme":"Other"},{"subitem_subject":"Collagen","subitem_subject_scheme":"Other"},{"subitem_subject":"Hydroxyapatite composite","subitem_subject_scheme":"Other"},{"subitem_subject":"Scaffold","subitem_subject_scheme":"Other"},{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"For reconstruction and regeneration of hard tissues, scaffold biomaterials with large size pores and high porosity are important, in addition to their roles as supporting frames. To develop a new biodegradable scaffold biomaterial, CO3Ap, which has crystallinity and a chemical composition similar to bone, was synthesized at pH 7.4 and 60°C. Then, the CO3Ap was mixed with a neutralized collagen gel and the CO3Ap-collagen mixtures with different kinds of CO3Ap contents and porosity were lyophilized into sponges. Scanning electron micrography (SEM) observation of CO3Ap-collagen sponges showed favorable pores for cell invasion. Approximately 50–300 μm size pores appeared to continue through the bulk. Higher magnification of the sponge showed a better adhesion between CO3Ap crystals and collagen. X-ray high-resolution microtomography revealed a clear image of the 3D structure of the sponges. The porosity of 0, 70 and 90%(w/w) CO3Ap-collagen sponges was 79.2±2.8%, 72.6±2.4% and 48.9±6.1%, respectively. The 70%(w/w) CO3Ap-collagen sponge appeared to be the most favorable biomaterial from the viewpoint of natural bone properties. Mouse osteoblast MC3T3-E1 cells were cultured in αMEM with 10% FCS for 2 weeks. Hematoxylin–eosin staining confirmed osteoblast cells invaded well into the CO3Ap-collagen sponge. These sponges are expected to be used as hard tissue scaffold biomaterials for therapeutic uses.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0142-9612","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00110092","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"2577"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"13","bibliographicPageEnd":"2583","bibliographicPageStart":"2577","bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"Biomaterials"},{"bibliographic_title":"Biomaterials"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_b1a7d7d4d402bcce","subitem_version_type":"AO"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.biomaterials.2003.09.071","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1016/j.biomaterials.2003.09.071","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"Biomaterials_25_2577.pdf","filesize":[{"value":"1.5 MB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2006485/files/Biomaterials_25_2577.pdf"},"version_id":"621488fd-98a3-4a78-88cd-7098e0c4228c"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"21545"},"item_title":"Characterization of CO3Ap-collagen sponges using X-ray high-resolution microtomography","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2006485","relation_version_is_last":true,"title":["Characterization of CO3Ap-collagen sponges using X-ray high-resolution microtomography"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-21T07:40:52.948193+00:00"}