{"created":"2025-02-21T03:22:45.536557+00:00","id":2006483,"links":{},"metadata":{"_buckets":{"deposit":"ffbc622b-1e5e-4592-b6b9-7e126b15ddde"},"_deposit":{"created_by":41,"id":"2006483","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2006483"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02006483","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"The roles of Syx5 in Golgi morphology and Rhodopsin transport in Drosophila photoreceptors","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Satoh, Takunori ","creatorNameLang":"en"}],"familyNames":[{"familyName":"Satoh","familyNameLang":"en"}],"givenNames":[{"givenName":"Takunori ","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nakamura , Yuri","creatorNameLang":"en"}],"familyNames":[{"familyName":"Nakamura ","familyNameLang":"en"}],"givenNames":[{"givenName":"Yuri","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Satoh K. , Akiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"Satoh K. ","familyNameLang":"en"}],"givenNames":[{"givenName":"Akiko","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2016. Published by The Company of Biologists Ltd ,This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed."}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Syx5","subitem_subject_scheme":"Other"},{"subitem_subject":"Rhodopsin","subitem_subject_scheme":"Other"},{"subitem_subject":"ER","subitem_subject_scheme":"Other"},{"subitem_subject":"Golgi","subitem_subject_scheme":"Other"},{"subitem_subject":"Vesicle cluster","subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"SNAREs (SNAP receptors) are the key components of protein complexes that drive membrane fusion. Here, we report the function of a SNARE, Syntaxin 5 (Syx5), in the development of photoreceptors in Drosophila. In wild-type photoreceptors, Syx5 localizes to cis-Golgi, along with cis-Golgi markers: Rab1 and GM130. We observed that Syx5-deficient photoreceptors show notable accumulation of these cis-Golgi markers accompanying drastic accumulation of vesicles between endoplasmic reticulum (ER) and Golgi cisternae. Extensive analysis of Rh1 (rhodopsin 1) trafficking revealed that in Syx5-deficient photoreceptors, Rh1 is exported from the ER with normal kinetics, retained in the cis-Golgi region along with GM130 for a prolonged period, and then subsequently degraded presumably by endoplasmic reticulum-associated protein degradation (ERAD) after retrieval to the ER. Unlike our previous report of Rab6-deficient photoreceptors – where two apical transport pathways are specifically inhibited – vesicle transport pathways to all plasma membrane domains are inhibited in Syx5-deficient photoreceptors, implying that Rab6 and Syx5 are acting in different steps of intra-Golgi transport. These results indicate that Syx5 is crucial for membrane protein transport, presumably during ER-derived vesicle fusion to form cis-Golgi cisternae.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"The Company of Biologists Ltd."}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"2046-6390","subitem_source_identifier_type":"ISSN"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"1420"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-08","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"1430","bibliographicPageStart":"1420","bibliographicVolumeNumber":"5","bibliographic_titles":[{"bibliographic_title":"Biology Open "},{"bibliographic_title":"Biology Open "}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1242/bio.020958","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://bio.biologists.org/content/5/10/1420","subitem_relation_type_select":"URI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"1420.full.pdf","filesize":[{"value":"9.4 MB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2006483/files/1420.full.pdf"},"version_id":"1577c435-13d3-4c27-8720-19939b838351"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"46876"},"item_title":"The roles of Syx5 in Golgi morphology and Rhodopsin transport in Drosophila photoreceptors","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2006483","relation_version_is_last":true,"title":["The roles of Syx5 in Golgi morphology and Rhodopsin transport in Drosophila photoreceptors"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-21T07:40:41.922506+00:00"}