{"created":"2025-02-21T03:21:58.939685+00:00","id":2006457,"links":{},"metadata":{"_buckets":{"deposit":"b6d95ceb-3b07-429d-93f1-d55195904df8"},"_deposit":{"created_by":41,"id":"2006457","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2006457"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02006457","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Changes in Otx2 and Parvalbumin Immunoreactivity in the Superior Colliculus in the Platelet-Derived Growth Factor Receptor-beta Knockout Mice","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Zhao, Juanjuan","creatorNameLang":"en"}],"familyNames":[{"familyName":"Zhao","familyNameLang":"en"}],"givenNames":[{"givenName":"Juanjuan","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Urakawa, Susumu","creatorNameLang":"en"}],"familyNames":[{"familyName":"Urakawa","familyNameLang":"en"}],"givenNames":[{"givenName":"Susumu","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Matsumoto, Jumpei","creatorNameLang":"en"}],"familyNames":[{"familyName":"Matsumoto","familyNameLang":"en"}],"givenNames":[{"givenName":"Jumpei","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Li, Ruixi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Li","familyNameLang":"en"}],"givenNames":[{"givenName":"Ruixi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ishii, Yoko","creatorNameLang":"en"}],"familyNames":[{"familyName":"Ishii","familyNameLang":"en"}],"givenNames":[{"givenName":"Yoko","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sasahara, Masakiyo","creatorNameLang":"en"}],"familyNames":[{"familyName":"Sasahara","familyNameLang":"en"}],"givenNames":[{"givenName":"Masakiyo","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Peng, Yuwen","creatorNameLang":"en"}],"familyNames":[{"familyName":"Peng","familyNameLang":"en"}],"givenNames":[{"givenName":"Yuwen","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ono, Taketoshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"Ono","familyNameLang":"en"}],"givenNames":[{"givenName":"Taketoshi","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nishijo, Hisao","creatorNameLang":"en"}],"familyNames":[{"familyName":"Nishijo","familyNameLang":"en"}],"givenNames":[{"givenName":"Hisao","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"Copyright © 2013 Juanjuan Zhao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited."}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"The superior colliculus (SC), a relay nucleus in the subcortical visual pathways, is implicated in socioemotional behaviors. Homeoprotein Otx2 and β subunit of receptors of platelet-derived growth factor (PDGFR-β) have been suggested to play an important role in development of the visual system and development and maturation of GABAergic neurons. Although PDGFR-β-knockout (KO) mice displayed socio-emotional deficits associated with parvalbumin (PV-)immunoreactive (IR) neurons, their anatomical bases in the SC were unknown. In the present study, Otx2 and PV-immunolabeling in the adult mouse SC were investigated in the PDGFR-β KO mice. Although there were no differences in distribution patterns of Otx2 and PV-IR cells between the wild type and PDGFR-β KO mice, the mean numbers of both of the Otx2- and PV-IR cells were significantly reduced in the PDGFR-β KO mice. Furthermore, average diameters of Otx2- and PV-IR cells were significantly reduced in the PDGFR-β KO mice. These findings suggest that PDGFR-β plays a critical role in the functional development of the SC through its effects on Otx2- and PV-IR cells, provided specific roles of Otx2 protein and PV-IR cells in the development of SC neurons and visual information processing, respectively.","subitem_description_language":"en"},{"subitem_description":"This work was supported partly by JSPS Asian Core Program, and the Ministry of Education, Science, Sports and Culture, Grant-in-Aid for Scientific Research (B) (25290005).","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Hindawi Publishing Corporation"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"2314-6133","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"2314-6141","subitem_source_identifier_type":"ISSN"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"848265"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-11","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"848265","bibliographicVolumeNumber":"2013","bibliographic_titles":[{"bibliographic_title":"BioMed Research International"},{"bibliographic_title":"BioMed Research International"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1155/2013/848265","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1155/2013/848265","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"24319691","subitem_relation_type_select":"PMID"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"848265.pdf","filesize":[{"value":"7.3 MB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2006457/files/848265.pdf"},"version_id":"f862a99c-32f0-4c7d-a33e-edec76812884"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"47056"},"item_title":"Changes in Otx2 and Parvalbumin Immunoreactivity in the Superior Colliculus in the Platelet-Derived Growth Factor Receptor-beta Knockout Mice","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2006457","relation_version_is_last":true,"title":["Changes in Otx2 and Parvalbumin Immunoreactivity in the Superior Colliculus in the Platelet-Derived Growth Factor Receptor-beta Knockout Mice"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-21T07:38:09.102948+00:00"}