| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
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|
タイトル |
Identification of Vanabin-interacting protein 1 (VIP1) from blood cells of the vanadium-rich ascidian Ascidia sydneiensis same |
|
言語 |
en |
| 作成者 |
Ueki, Tatsuya
Shintaku, Koki
Yonekawa, Yuki
Takatsu, Nariaki
Yamada, Hiroshi
Hamada, Yoshiyuki
Hirota, Hiroshi
Michibata, Hitoshi
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| アクセス権 |
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|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
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|
権利情報 |
Copyright (c) 2007 Elsevier B.V. |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
vanadium |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
ascidian |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
metal-binding protein |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
protein-protein interaction |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
460 |
| 内容記述 |
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|
内容記述 |
Several species of ascidians, the so-called tunicates, accumulate extremely high levels of vanadium ions in their blood cells. We previously identified a family of vanadium-binding proteins, named Vanabins, from blood cells and blood plasma of a vanadium-rich ascidian, Ascidia sydneiensis samea. The 3-dimensional structure of Vanabin2, the predominant vanadium-binding protein in blood cells, has been revealed, and the vanadium-binding properties of Vanabin2 have been studied in detail. Here, we used Far Western blotting to identify a novel protein that interacts with Vanabin2 from a blood cell cDNA library. The protein, named Vanabin-interacting protein 1 (VIP1), was localized in the cytoplasm of signet ring cells and giant cells. Using a two-hybrid method, we revealed that VIP1 interacted with Vanabins 1, 2, 3, and 4 but not with Vanabin P. The N-terminal domain of VIP1 was shown to be important for the interaction. Further, Vanabin1 was found to interact with all of the other Vanabins. These results suggest that VIP1 and Vanabin1 act as metal chaperones or target proteins in vanadocytes. |
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言語 |
en |
| 出版者 |
|
|
出版者 |
Elsevier B.V. |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
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|
識別子タイプ |
DOI |
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関連識別子 |
10.1016/j.bbagen.2007.02.003 |
| 関連情報 |
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|
識別子タイプ |
PMID |
|
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関連識別子 |
17376595 |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1016/j.bbagen.2007.02.003 |
| 収録物識別子 |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00564679 |
| 収録物識別子 |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0304-4165 |
| 開始ページ |
|
|
開始ページ |
951 |
| 書誌情報 |
Biochimica et Biophysica Acta - General Subjects
Biochimica et Biophysica Acta - General Subjects
巻 1770,
号 6,
p. 951-957,
発行日 2007-06
|
| 旧ID |
17246 |
BBA_02_17.pdf (832.7 KB)
