| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Interleukin-1 inhibits voltage-dependent P/Q-type Ca2+ channel associated with the inhibition of the rise of intracellular free Ca2+ concentration and catecholamine release in adrenal chromaffin cells |
|
言語 |
en |
| 作成者 |
Morita, Katsuya
Miyasako, Takanori
Kitayama, Shigeo
Dohi, Toshihiro
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2004 Elsevier B.V |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
IL-1 |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Voltage-dependent Ca2+ channel |
| 主題 |
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|
主題Scheme |
Other |
|
主題 |
P/Q-type Ca2+ channel |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Catecholamine release |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Ca2+ |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Adrenal chromaffin cells |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
Effects of interleukin (IL) on intracellular free Ca2+ concentration ([Ca2+]i) rise and catecholamine (CA) release were examined in isolated, cultured bovine adrenal chromaffin cells. IL-1α and IL-1β inhibited the rise of [Ca2+]i and CA release induced by acetylcholine (ACh) and excess KCl both in normal and in Ca2+-sucrose medium. IL-1 receptor antagonist, IL-1RA by pretreatment blocked the inhibitory actions of IL-1. IL-1α reduced CA release induced by veratridine in normal medium but not in the presence of diltiazem. Analysis using specific blockers for voltage-operated Ca2+ channels revealed that IL-1α specifically inhibited the P/Q-type Ca2+ channel to reduce [Ca2+]i rise induced by excess KCl. IL-1 did not affect [Ca2+]i rise induced either by bradykinin or caffeine in Ca2+- deprivated medium or via activation of store-operated Ca2+ channel. The inhibitory effects of IL-1 were blocked by pretreatments of cells with herbimycin A, U0126 and PD 98054, but not with SB202190, SP 600125 or pertussis toxin (PTX), inhibited the induction of the inhibitory action of IL-1.These results demonstrated that IL-1 inhibits stimulation-evoked [Ca2+]i rise and CA release in chromaffin cells by blocking voltage-operated P/O-type Ca2+ channels. The inhibitory action of IL-1 may be mediated through tyrosine kinase and MEK/ERK pathways. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Elsevier B.V |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.bbagen.2004.04.012 |
| 関連情報 |
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|
識別子タイプ |
PMID |
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|
関連識別子 |
15279887 |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1016/j.bbagen.2004.04.012 |
| 収録物識別子 |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0304-4165 |
| 収録物識別子 |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00564679 |
| 開始ページ |
|
|
開始ページ |
160 |
| 書誌情報 |
Biochimica et Biophysica Acta
Biochimica et Biophysica Acta
巻 1673,
号 3,
p. 160-169,
発行日 2004-08-04
|
| 旧ID |
112 |
BBA_1673-3_160-169_2004-8-4.pdf (1.2 MB)
