{"created":"2025-02-21T03:19:40.345120+00:00","id":2006381,"links":{},"metadata":{"_buckets":{"deposit":"beba1442-a1a5-4d0b-b8bc-b51ffa05890d"},"_deposit":{"created_by":41,"id":"2006381","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2006381"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02006381","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"3,3′-Diindolylmethane disrupts the endoplasmic reticulum and nuclear envelope in Schizosaccharomyces pombe","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Wang, Kaiyu","creatorNameLang":"en"}],"familyNames":[{"familyName":"Wang","familyNameLang":"en"}],"givenNames":[{"givenName":"Kaiyu","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Seol, Hyekyung","creatorNameLang":"en"}],"familyNames":[{"familyName":"Seol","familyNameLang":"en"}],"givenNames":[{"givenName":"Hyekyung","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Emami, Parvaneh","creatorNameLang":"en"}],"familyNames":[{"familyName":"Emami","familyNameLang":"en"}],"givenNames":[{"givenName":"Parvaneh","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nagai, Hideto","creatorNameLang":"en"}],"familyNames":[{"familyName":"Nagai","familyNameLang":"en"}],"givenNames":[{"givenName":"Hideto","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ueno, Masaru","creatorNameLang":"en"}],"familyNames":[{"familyName":"Ueno","familyNameLang":"en"}],"givenNames":[{"givenName":"Masaru","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"embargoed access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_f1cf"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2024. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/","subitem_rights_language":"en"},{"subitem_rights":"This is not the published version. Please cite only the published version. ","subitem_rights_language":"en"},{"subitem_rights":"この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。","subitem_rights_language":"ja"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"3,3′-Diindolylmethane","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Nuclear envelope","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Endoplasmic reticulum","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ESCRT-III","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Lipid","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"3,3′-Diindolylmethane is recognized for its anti-cancer activities in various pathways, though its mechanism remains to be fully elucidated. Previous studies have shown that 3,3′-Diindolylmethane disturbed the localization of Cut11, a nuclear pore complex subunit in Schizosaccharomyces pombe. This study further reveals that in Schizosaccharomyces pombe, 3,3′-Diindolylmethane also disrupts other components of nuclear envelope, causing GFP-NLS leakage, making it evident that 3,3′-Diindolylmethane disrupts the nuclear envelope. 3,3′-Diindolylmethane also disturbs the localization of GFP-ADEL and Ost4, which are endoplasmic reticulum lumen proteins and membrane proteins respectively, suggesting the function of 3,3′-Diindolylmethane on endoplasmic reticulum disturbance. The nuclear envelope repairment, normal nuclear envelope physical properties, and lipid metabolism homeostasis are crucial for cell survival in the presence of 3,3′-Diindolylmethane. These findings provide new insights into the understanding and development of 3,3′-Diindolylmethane as an anti-cancer agent.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186901218":{"attribute_name":"Funding Reference","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"23K05865","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K05865/"},"subitem_award_titles":[{"subitem_award_title":"がん転移阻止を目指したブロッコリー由来成分DIMによる核膜損傷機構の解明","subitem_award_title_language":"ja"}],"subitem_funder_names":[{"subitem_funder_name":"日本学術振興会","subitem_funder_name_language":"ja"}]},{"subitem_award_titles":[{"subitem_award_title":"がん転移阻止を目指したブロッコリー由来成分DIMによる核膜損傷機構の解明","subitem_award_title_language":"ja"}],"subitem_funder_names":[{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"150724"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-09-24","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"150724","bibliographicVolumeNumber":"733","bibliographic_titles":[{"bibliographic_title":"Biochemical and Biophysical Research Communications","bibliographic_titleLang":"en"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.bbrc.2024.150724","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2025-09-24"}],"displaytype":"simple","fileDate":[{"fileDateType":"Available","fileDateValue":"2025-09-24"}],"filename":"BBRC_733_150724.pdf","filesize":[{"value":"7.9 MB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2006381/files/BBRC_733_150724.pdf"},"version_id":"36ede903-a689-48a2-aecd-2a8666cd30d3"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"55839"},"item_1732772494514":{"attribute_name":"備考","attribute_value":"The full-text file will be made open to the public on 24 September 2025 in accordance with publisher's 'Terms and Conditions for Self-Archiving'"},"item_title":"3,3′-Diindolylmethane disrupts the endoplasmic reticulum and nuclear envelope in Schizosaccharomyces pombe","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-12-11"},"publish_date":"2024-12-11","publish_status":"0","recid":"2006381","relation_version_is_last":true,"title":["3,3′-Diindolylmethane disrupts the endoplasmic reticulum and nuclear envelope in Schizosaccharomyces pombe"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-21T07:28:09.387979+00:00"}