| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2025-01-15 |
| タイトル |
|
|
タイトル |
Histidine-containing dipeptide deficiency links to hyperactivity and depression-like behaviors in old female mice |
|
言語 |
en |
| 作成者 |
Braga, Jason D.
Komaru, Takumi
Umino, Mitsuki
Nagao, Tomoka
Matsubara, Kiminori
Egusa, Ai
Yanaka, Noriyuki
Nishimura, Toshihide
Kumrungsee, Thanutchaporn
|
| アクセス権 |
|
|
アクセス権 |
embargoed access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_f1cf |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
© 2024. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is not the published version. Please cite only the published version. |
| 権利情報 |
|
|
言語 |
ja |
|
権利情報 |
この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。 |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Homocarnosine |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
GABA |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Hyperactivity |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Anxiety |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Depression |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
CARNS1 |
| 内容記述 |
|
|
内容記述 |
Carnosine, anserine, and homocarnosine are histidine-containing dipeptides (HCDs) abundant in the skeletal muscle and nervous system in mammals. To date, studies have extensively demonstrated effects of carnosine and anserine, the predominant muscular HCDs, on muscular functions and exercise performance. However, homocarnosine, the predominant brain HCD, is underexplored. Moreover, roles of homocarnosine and its related HCDs in the brain and behaviors remain poorly understood. Here, we investigated potential roles of endogenous brain homocarnosine and its related HCDs in behaviors by using carnosine synthase-1-deficient (Carns1−/−) mice. We found that old Carns1−/− mice (female 12 months old) exhibited hyperactivity- and depression-like behaviors with higher plasma corticosterone levels on light-dark transition and forced swimming tests, but had no defects in spontaneous locomotor activity, repetitive behavior, olfactory functions, and learning and memory abilities, as compared with their age-matched wild-type (WT) mice. We confirmed that homocarnosine and its related HCDs were deficient across brain areas of Carns1−/− mice. Homocarnosine deficiency exhibited small effects on its constituent γ-aminobutyric acid (GABA) in the brain, in which GABA levels in hypothalamus and olfactory bulb were higher in Carns1−/− mice than in WT mice. In WT mice, homocarnosine and GABA were highly present in hypothalamus, thalamus, and olfactory bulb, and their brain levels did not decrease in old mice when compared with younger mice (3 months old). Our present findings provide new insights into roles of homocarnosine and its related HCDs in behaviors and neurological disorders. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
This work was supported by Grant-in-Aid for Early Career Scientists (No. 21K14804 to T. K.) from the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT, Tokyo) and the 2021 Danone Institute of Japan Foundation (DIJF) Research Grant (Tokyo, Japan) (to T.K.). |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Elsevier |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.bbrc.2024.150361 |
| 助成情報 |
|
|
|
助成機関名 |
日本学術振興会 |
|
|
言語 |
ja |
|
|
研究課題番号URI |
https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-21K14804/ |
|
|
研究課題番号 |
21K14804 |
|
|
研究課題名 |
カルノシンの骨格筋再生における生理的役割の解明、および応用 |
|
|
言語 |
ja |
| 助成情報 |
|
|
|
助成機関名 |
Japan Society for the Promotion of Science |
|
|
言語 |
en |
|
|
研究課題名 |
カルノシンの骨格筋再生における生理的役割の解明、および応用 |
|
|
言語 |
ja |
| 書誌情報 |
en : Biochemical and Biophysical Research Communications
巻 729,
号 150361,
発行日 2024-07-05
|
| 旧ID |
56114 |
| 備考 |
The full-text file will be made open to the public on 5 July 2025 in accordance with publisher's 'Terms and Conditions for Self-Archiving' |
BBRC_729_150361.pdf (1.1 MB)
