{"created":"2025-02-21T03:19:34.680820+00:00","id":2006378,"links":{},"metadata":{"_buckets":{"deposit":"868d7134-8f80-4186-8f3e-8bebbbb4a5d0"},"_deposit":{"created_by":41,"id":"2006378","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2006378"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02006378","sets":["1730444907710"]},"author_link":[],"control_number":"2006378","item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Bqt4 affects relative movement between SPB and nucleolus in fission yeast","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Wang, Kaiyu","creatorNameLang":"en"}],"familyNames":[{"familyName":"Wang","familyNameLang":"en"}],"givenNames":[{"givenName":"Kaiyu","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ito, Hiroaki","creatorNameLang":"en"}],"familyNames":[{"familyName":"Ito","familyNameLang":"en"}],"givenNames":[{"givenName":"Hiroaki","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kanoh , Junko","creatorNameLang":"en"}],"familyNames":[{"familyName":"Kanoh","familyNameLang":"en"}],"givenNames":[{"givenName":"Junko","givenNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ueno, Masaru","creatorNameLang":"en"}],"familyNames":[{"familyName":"Ueno","familyNameLang":"en"}],"givenNames":[{"givenName":"Masaru","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"© 2024. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/","subitem_rights_language":"en"},{"subitem_rights":"This is not the published version. Please cite only the published version.","subitem_rights_language":"en"},{"subitem_rights":"この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。","subitem_rights_language":"ja"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Bqt4","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Nuclear envelope","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Movement dynamics","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Mechanical property","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Movement dynamics in the nucleus involve various biological processes, including DNA repair, which is crucial for cancer prevention. Changes in the movement of the components of the nucleus indicate the changes in movement dynamics in the nucleus. In Schizosaccharomyces pombe, the inner nuclear membrane protein Bqt4 plays an essential role in attaching telomeres to the nuclear envelope. We observed that the deletion of bqt4+ caused a significant decrease in the mean square displacement (MSD) calculated from the distance between the nucleolar center and spindle pole body (SPB), hereafter referred to as MSD(SPB-Nucleolus). The MSD(SPB-Nucleolus) decrease in bqt4Δ was microtubule-dependent. The Rap1-binding ability loss mutant, bqt4F46A, and nonspecific DNA-binding ability mutants, bqt43E-A, did not exhibit an MSD(SPB-Nucleolus) decrease compared to the WT. Moreover, the bqt43E-A rap1Δ double mutant and 1–262 amino acids truncated mutant bqt4ΔN (263–432), which does not have either Rap1-binding or nonspecific DNA-binding abilities, did not exhibit the MSD(SPB-Nucleolus) decrease to the same extent as bqt4Δ. These results suggest that the unknown function of Bqt4 in the C-terminal domain is essential for the maintenance of the pattern of relative movement between SPB and the nucleolus.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"MU is supported by MEXT/JSPS KAKENHI, Grant Number 23K05865, and Platform Project for Supporting in Drug Discovery and Life Science Research (Platform for Dynamic Approaches to Living System) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) and Japan Agency for Medical Research and Development (AMED).","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186901218":{"attribute_name":"Funding Reference","attribute_value_mlt":[{"subitem_award_numbers":{"subitem_award_number":"23K05865","subitem_award_uri":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K05865/"},"subitem_award_titles":[{"subitem_award_title":"がん転移阻止を目指したブロッコリー由来成分DIMによる核膜損傷機構の解明","subitem_award_title_language":"ja"}],"subitem_funder_names":[{"subitem_funder_name":"日本学術振興会","subitem_funder_name_language":"ja"}]},{"subitem_award_titles":[{"subitem_award_title":"がん転移阻止を目指したブロッコリー由来成分DIMによる核膜損傷機構の解明","subitem_award_title_language":"ja"}],"subitem_funder_names":[{"subitem_funder_name":"Japan Society for the Promotion of Science","subitem_funder_name_language":"en"}]}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"149970"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-04-23","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"149970","bibliographicVolumeNumber":"714","bibliographic_titles":[{"bibliographic_title":"Biochemical and Biophysical Research Communications","bibliographic_titleLang":"en"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.bbrc.2024.149970","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2025-04-23"}],"displaytype":"simple","fileDate":[{"fileDateType":"Available","fileDateValue":"2025-04-23"}],"filename":"BBRC_714_149970.pdf","filesize":[{"value":"3.6 MB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2006378/files/BBRC_714_149970.pdf"},"version_id":"4f0d23d9-d098-4b93-bec4-2d94d52a25be"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"55838"},"item_title":"Bqt4 affects relative movement between SPB and nucleolus in fission yeast","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-12-11"},"publish_date":"2024-12-11","publish_status":"0","recid":"2006378","relation_version_is_last":true,"title":["Bqt4 affects relative movement between SPB and nucleolus in fission yeast"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-04-30T00:18:19.085074+00:00"}