| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Peritoneal injection of fucoidan suppresses the increase of plasma IgE induced by OVA-sensitization |
|
言語 |
en |
| 作成者 |
Yanase, Yuhki
Hiragun, Takaaki
Uchida, Kazue
Ishii, Kaori
Oomizu, Souichi
Suzuki, Hidenori
Mihara, Shoji
Iwamoto, Kazumasa
Matsuo, Hiroaki
Onishi, Nobukazu
Kameyoshi, Yoshikazu
Hide, Michihiro
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2009 Elsevier Inc. |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Fucoidan |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
B cells |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
T cells |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
IgE |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Ovalbumin (OVA) |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
We previously reported that fucoidan, a dietary fiber purified from seaweed, inhibited IgE production by B cells in vitro. In this study, we examined the effect of fucoidan on IgE production in vivo. The OVA-induced increase of plasma IgE was significantly suppressed when fucoidan was intraperitoneally, but not orally, administered prior to the first immunization with OVA. The production of IL-4 and IFN-gamma in response to OVA in spleen cells isolated from OVA-sensitized mice treated with fucoidan in vivo was lower than that from mice treated without fucoidan. Moreover, the flow cytometric analysis and ELISpot assay revealed that the administration of fucoidan Suppressed a number of IgE-expressing and IgE-secreting B cells, respectively. These results indicate that fucoidan inhibits the increase of plasma IgE through the suppression of IgE-producing B cell population, and the effect of fucoidan in VIVO is Crucially dependent on the route and timing of its administration. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Academic Press Inc |
| 出版者 |
|
|
出版者 |
Elsevier Science |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.bbrc.2009.07.031 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1016/j.bbrc.2009.07.031 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0006-291X |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00564395 |
| 開始ページ |
|
|
開始ページ |
435 |
| 書誌情報 |
Biochemical and Biophysical Research Communications
Biochemical and Biophysical Research Communications
巻 387,
号 3,
p. 435-439,
発行日 2009-09-25
|
| 旧ID |
28861 |
BBRC_387_435.pdf (436.3 KB)
