| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
Differentiation of a hepatic phenotype after heterotropic transplantation of heart, kidney, brain, and skin tissues into liver in F344 rats |
|
言語 |
en |
| 作成者 |
Watanabe, Hiromitsu
Ochiya, Takahiro
Ueda, Shinobu
Kominami, Yoko
Gon, Rina
Nishiki, Masayo
Hayashi, Masaomi
Sasaki, Atsushi
Shiraishi, Miho
Kashimoto, Naoki
Myojin, Yuki
Kamiya, Kenji
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
Copyright (c) 2007 Elsevier Inc. All rights reserved. |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Differentiation |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Hepatocyte |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Transplantation |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Stem cells |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Liver |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
GFP |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
Transgenic rat |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
CCl4 |
| 主題 |
|
|
主題Scheme |
NDC |
|
主題 |
490 |
| 内容記述 |
|
|
内容記述 |
While organ-specific stem cells with roles in tissue injury repair have been documented, their pathogenic significance in diseases and the factors potentially responsible for their activation remain largely unclear. In the present study, heart, kidney, brain, and skin samples from F344 transgenic rats carrying the GFP gene were transplanted into normal F344 rat liver one day after an intraperitoneal injection (i.p.) of carbon tetrachloride (CCl4) to test their differentiation capacity. The transplantation was carried out by female donors to male recipients, and vice versa. One week after transplantation, GFP antigen-positive cells with phenotypic characteristics of hepatocytes were noted. After two weeks, their extent increased, and at 4 weeks, large areas of strongly GFP-stained cells developed. All recipient livers had GFP antigen-positive hepatocyte cells. PCR analysis coupled with laser capture micro-dissection (LCM) revealed those cells to contain GFP DNA. Thus, our results indicate that tissue stem cells have multipotential ability, differentiating into hepatocytes when transplanted into an injured liver. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Elsevier |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.bbrc.2006.12.236 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
http://dx.doi.org/10.1016/j.bbrc.2006.12.236 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0006-291X |
| 収録物識別子 |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00564395 |
| 開始ページ |
|
|
開始ページ |
841 |
| 書誌情報 |
Biochemical and Biophysical Research Communications
Biochemical and Biophysical Research Communications
巻 354,
号 4,
p. 841-845,
発行日 2007-03-23
|
| 旧ID |
31111 |
BBRC_354_841.pdf (1.6 MB)
