{"created":"2025-02-21T03:19:07.936012+00:00","id":2006366,"links":{},"metadata":{"_buckets":{"deposit":"5a4d46bd-7fee-4f22-a012-89b8135aa0fa"},"_deposit":{"created_by":41,"id":"2006366","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2006366"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02006366","sets":["1730444907710"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"The inhibition of the nuclear transport of caspase-7 by its prodomain","subitem_title_language":"en"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yaoita, Yoshio","creatorNameLang":"en"}],"familyNames":[{"familyName":"Yaoita","familyNameLang":"en"}],"givenNames":[{"givenName":"Yoshio","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2002 Elsevier Science (USA)."}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"caspase","subitem_subject_scheme":"Other"},{"subitem_subject":"nuclear localization","subitem_subject_scheme":"Other"},{"subitem_subject":"prodomain","subitem_subject_scheme":"Other"},{"subitem_subject":"apoptosis","subitem_subject_scheme":"Other"},{"subitem_subject":"cytotoxic activity","subitem_subject_scheme":"Other"},{"subitem_subject":"460","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Apoptosis is a major form of cell death, characterized by a series of the morphological changes induced by cleaving cytoplasmic and nuclear proteins via active caspases. The data presented here show, by the fluorescence microscopic and the immunoblotting analyses, that a prodomain of caspase-7 inhibits its nuclear translocation and apoptosis-inducing activity. This nuclear localization is dependent on the presence of a basic tetrapeptide that is conserved in mammalian and Xenopus caspase-7 and that is located downstream of a cleavage site between a prodomain and a catalytic protease domain. Furthermore, an attachment of caspase-7 prodomain (31 amino acids) represses the nuclear transport of a fusion protein of a heterologous protein and the caspase-7 nuclear localization signal (19 amino acids), suggesting that the inhibition of the nuclear localization by the prodomain is mediated by the interaction of these short peptides.","subitem_description_language":"en"}]},"item_1617186643794":{"attribute_name":"Publisher","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617186920753":{"attribute_name":"Source Identifier","attribute_value_mlt":[{"subitem_source_identifier":"0006-291X","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00564395","subitem_source_identifier_type":"NCID"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"79"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-02-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"84","bibliographicPageStart":"79","bibliographicVolumeNumber":"291","bibliographic_titles":[{"bibliographic_title":"Biochemical and Biophysical Research Communications"},{"bibliographic_title":"Biochemical and Biophysical Research Communications"}]}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_b1a7d7d4d402bcce","subitem_version_type":"AO"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1006/bbrc.2002.6408","subitem_relation_type_select":"DOI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1006/bbrc.2002.6408","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"BBRC_291-1_79.pdf","filesize":[{"value":"1.1 MB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2006366/files/BBRC_291-1_79.pdf"},"version_id":"12c4b7b4-0724-4109-a2ca-5274f1f57ed4"}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"20660"},"item_title":"The inhibition of the nuclear transport of caspase-7 by its prodomain","item_type_id":"40003","owner":"41","path":["1730444907710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2006366","relation_version_is_last":true,"title":["The inhibition of the nuclear transport of caspase-7 by its prodomain"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-21T07:26:31.740616+00:00"}