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Effects of local anesthesia of the cerebellum on classical fear conditioning in goldfish
https://hiroshima.repo.nii.ac.jp/records/2006359
https://hiroshima.repo.nii.ac.jp/records/200635973a5f1aa-b781-4eaf-91bc-a175dcfd8131
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
BBF_6_20.pdf (591.9 KB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||||
| タイトル | ||||||||||
| タイトル | Effects of local anesthesia of the cerebellum on classical fear conditioning in goldfish | |||||||||
| 言語 | en | |||||||||
| 作成者 |
Yoshida, Masayuki
× Yoshida, Masayuki
× Hirano, Ruriko
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| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 権利情報 | ||||||||||
| 権利情報 | Copyright (c) 2010 Yoshida and Hirano; licensee BioMed Central Ltd. | |||||||||
| 主題 | ||||||||||
| 主題Scheme | NDC | |||||||||
| 主題 | 480 | |||||||||
| 内容記述 | ||||||||||
| 内容記述 | Background: Besides the amygdala, of which emotion roles have been intensively studied, the cerebellum has also been demonstrated to play a critical role in simple classical fear conditioning in both mammals and fishes. In the present study, we examined the effect of local administration of the anesthetic agent lidocaine into the cerebellum on fear-related, classical heart-rate conditioning in goldfish. Methods: The effects of microinjection of the anesthetic agent lidocaine into the cerebellum on fear conditioning were investigated in goldfish. The fear conditioning paradigm was delayed classical conditioning with light as a conditioned stimulus and electric shock as an unconditioned stimulus; cardiac deceleration (bradycardia) was the conditioned response. Results: Injecting lidocaine into the cerebellum had no effect on the base heart rate, an arousal/orienting response to the novel stimulus (i.e., the first presentation of light), or an unconditioned response to electric shock. However, lidocaine injection greatly impaired acquisition of conditioned bradycardia. Lidocaine injection 60 min before the start of the conditioning procedure showed no effect on acquisition of conditioned bradycardia, indicating that the effect of lidocaine was reversible. Conclusions: The present results further confirm the idea that the cerebellum in teleost fish, as in mammals, is critically involved in classical fear conditioning. | |||||||||
| 言語 | en | |||||||||
| 出版者 | ||||||||||
| 出版者 | Biomed Central | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
| 関連情報 | ||||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | 10.1186/1744-9081-6-20 | |||||||||
| 関連情報 | ||||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | http://dx.doi.org/10.1186/1744-9081-6-20 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 1744-9081 | |||||||||
| 収録物識別子 | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA12050307 | |||||||||
| 書誌情報 |
Behavioral and Brain Functions Behavioral and Brain Functions 巻 6, 発行日 2010 |
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| 旧ID | 30127 | |||||||||
