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Topographic carotid vasoconstriction in the rostral ventrolateral medulla of rats
https://hiroshima.repo.nii.ac.jp/records/2006358
https://hiroshima.repo.nii.ac.jp/records/20063587f8fdbd0-db06-4866-a8f4-ffffad54e2bc
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AutonomicNeuroscience_229_102720.pdf (1.4 MB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2023-03-18 | |||||||
| タイトル | ||||||||
| タイトル | Topographic carotid vasoconstriction in the rostral ventrolateral medulla of rats | |||||||
| 言語 | en | |||||||
| 作成者 |
Takemoto, Yumi
× Takemoto, Yumi
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| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 権利情報 | ||||||||
| 権利情報 | © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||
| 権利情報 | ||||||||
| 権利情報 | This is not the published version. Please cite only the published version. この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。 | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Common carotid flow | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | RVLM | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | CVLM | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | L-cysteine | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Ionotropic excitatory amino acid receptors | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Rats | |||||||
| 内容記述 | ||||||||
| 内容記述 | The vascular beds of various cranial tissues receive common carotid flow, which contributes to blood flow redistribution associated with animal behaviors such as grooming, but the medullary autonomic regulation of carotid flow resistance (CAR) is poorly understood. This study is the first to examine the response sites of CAR in the rat rostral ventrolateral medulla (RVLM) presympathetic area to chemical stimulation by the ionotropic excitatory amino acid receptors activator L-cysteine. Arterial blood pressure and CAR were monitored in anesthetized rats which had a cranial window constructed above the ventral medulla. Mapping of L-cysteine microinjection in eight rats showed carotid vasoconstriction in the caudal part alone within the RVLM pressor area, which included contributions from other vascular beds, indicating localized topographic carotid vasoconstriction. Additional testing was performed on four types of denervated rats. A similar response map was obtained in six rats that received minimal lesions during surgery as well as in 10 rats with severed internal or external carotid nerves. However, the remaining three minimally lesioned rats showed extensive vasoconstriction of the RVLM pressor area including the rostral part, indicating lack of a topographic response. The topographic response of most rats might be state-dependent. Seven rats with complete cervical denervation showed no carotid vasoconstrictor response in the RVLM pressor area, indicating cervical sympathetic mediation of the responses. The topographic carotid vasoconstriction in response to L-cysteine may suggest differential roles of presympathetic neurons in the rostral and caudal parts of the RVLM in sympathetic carotid flow regulation. | |||||||
| 言語 | en | |||||||
| 内容記述 | ||||||||
| 内容記述タイプ | Other | |||||||
| 内容記述 | This work was supported by Japan Society for the Promotion of Science (JSPS), Grant-in-Aid for Scientific Research (Kakenhi) grant number JP18K06854. | |||||||
| 出版者 | ||||||||
| 出版者 | Elsevier | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | AO | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_b1a7d7d4d402bcce | |||||||
| 関連情報 | ||||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.1016/j.autneu.2020.102720 | |||||||
| 関連情報 | ||||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | https://doi.org/10.1016/j.autneu.2020.102720 | |||||||
| 収録物識別子 | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 1566-0702 | |||||||
| 開始ページ | ||||||||
| 開始ページ | 102720 | |||||||
| 書誌情報 |
Autonomic Neuroscience Autonomic Neuroscience 巻 229, p. 102720, 発行日 2020-12 |
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| 旧ID | 50434 | |||||||
| 備考 | Post-print version/PDF may be used in an institutional repository after an embargo period of 12 months. | |||||||
