| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2025-01-14 |
| タイトル |
|
|
タイトル |
Effect of Abdominal Aortic Calcification on Recurrence Following Initial Hepatectomy for Colorectal Liver Metastases |
|
言語 |
en |
| 作成者 |
IMAOKA, KOUKI
OHIRA, MASAHIRO
SHIMOMURA, MANABU
HATTORI, MINORU
BEKKI, TOMOAKI
SATO, KOKI
IMAOKA, YUKI
AKABANE, SHINTARO
NAKANO, RYOSUKE
YANO, TAKUYA
SAKAI, HIROSHI
HIRATA, FUMIHIRO
KURODA, SHINTARO
TAHARA, HIROYUKI
IDE, KENTARO
ISHIYAMA, KOHEI
KOBAYASHI, TSUYOSHI
TANAKA, YUKA
OHDAN, HIDEKI
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
© 2024 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved. |
| 権利情報 |
|
|
言語 |
en |
|
権利情報 |
This is not the published version. Please cite only the published version. |
| 権利情報 |
|
|
言語 |
ja |
|
権利情報 |
この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。 |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Aortic calcification |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
colorectal liver metastasis |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
tumor necrosis factor-related apoptosis-inducing ligand |
| 主題 |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
propensity score |
| 内容記述 |
|
|
内容記述 |
Background/Aim: The aim of the study was to analyze the association between abdominal aortic calcification (AAC) and patient prognosis following resection of colorectal liver metastases (CRLM). AAC potentially reflects intrahepatic immunity and is involved in tumor development and progression. However, the clinical effects of AAC on colorectal cancer (CRC) prognosis after curative-intent liver resection for CRLM remain unclear. Patients and Methods: We evaluated the effect of AAC on the clinical prognosis and metastatic patterns in 99 patients who underwent hepatectomy for CRLM between 2010 and 2019. Results: The high-AAC group had significantly worse overall survival (OS) and remnant liver recurrence rate (RR) after propensity score matching to adjust for differences in baseline characteristics of patients and tumors. In multivariate Cox regression analyses, high AAC volume was an independent risk factor for poor OS and liver RR, but not poor lung RR. The expression of tumor necrosis factor-related apoptosis-inducing ligand, known as an anti-tumor marker, in liver natural killer (NK) cells was lower in the high-AAC group than in the low-AAC group. Conclusion: High AAC volume showed a strong relationship with remnant liver RR after curative resection of CRLM. High AAC volume may be responsible for the suppression of anti-tumor activity of liver NK cells, which results in an increased risk of liver recurrence and poor prognosis. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
International Institute of Anticancer Research |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連情報 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.21873/anticanres.16854 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
1791-7530 |
| 開始ページ |
|
|
開始ページ |
649 |
| 書誌情報 |
en : Anticancer Research
巻 44,
号 2,
p. 649-658,
発行日 2024-02-02
|
| 旧ID |
56109 |
AnticancerRes_44_649.pdf (766.3 KB)
