| Item type |
デフォルトアイテムタイプ_（フル）(1) |
| 公開日 |
2023-03-18 |
| タイトル |
|
|
タイトル |
The acceleration of reproductive aging in Nrg1flox/flox;Cyp19-Cre female mice |
|
言語 |
en |
| 作成者 |
Umehara, Takashi
Kawai, Tomoko
Kawashima, Ikko
Tanaka, Katsuhiro
Okuda, Satoshi
Kitasaka, Hiroya
Richards, JoAnne S.
Shimada, Masayuki
|
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 権利情報 |
|
|
権利情報 |
© 2017 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
estrus cycle |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
female fertility |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
gonadotropins |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
ovarian aging |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
ovarian stroma |
| 主題 |
|
|
主題Scheme |
Other |
|
主題 |
steroidogenesis |
| 内容記述 |
|
|
内容記述 |
Irregular menstrual cycles, reduced responses to exogenous hormonal treatments, and altered endocrine profiles (high FSH/high LH/low AMH) are observed in women with increasing age before menopause. In this study, because the granulosa cell-specific Nrg1 knockout mice (gcNrg1KO) presented ovarian and endocrine phenotypes similar to older women, we sought to understand the mechanisms of ovarian aging and to develop anewstrategy for improving fertility in older women prior to menopause. In the ovary of 6-month-old gcNrg1KO mice, follicular development was blocked in bilayer secondary follicles and heterogeneous cells accumulated in ovarian stroma. The heterogeneous cells in ovarian stroma were distinguished as two different types: (i) the LH receptor-positive endocrine cells and (ii) actin-rich fibrotic cells expressing collagen. Both the endocrine and fibrotic cells disappeared following long-term treatment with a GnRH antagonist, indicating that the high levels of serum LH induced the survival of both cell types and the abnormal endocrine profile to reduce fertility. Moreover, follicular development to the antral stages was observed with reduced LH and the disappearance of the abnormal stromal cells. Mice treated with the GnRH antagonist regained normal, recurrent estrous cycles and continuously delivered pups for at least for 3 months. We conclude that endocrine and matrix alternations occur within the ovarian stroma with increasing age and that abolishing these alternations resets the cyclical release of LH. Thus, GnRH antagonist treatments might provide a new, noninvasive strategy for improving fertility in a subset of aging women before menopause. |
|
言語 |
en |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
This work was supported in part by The Japan Society for the Promotion of Science (JSPS) KAKENHI, JP24688028, JP 16H05017 (to MS) and JP15J05331 (to TU), by Japan Agency for Medical Research and Development (AMED) 16gk0110015 h0001 (to MS), and by National Institute of Health (NIH)-HD-076980 (to JSR). |
| 出版者 |
|
|
出版者 |
The Anatomical Society and John Wiley & Sons Ltd. |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 関連情報 |
|
|
|
関連名称 |
Aging Cell (2017) 16, pp1288–1299 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1111/acel.12662 |
| 関連情報 |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1111/acel.12662 |
| 収録物識別子 |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1474-9718 |
| 収録物識別子 |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1474-9726 |
| 開始ページ |
|
|
開始ページ |
1288 |
| 書誌情報 |
Aging Cell
Aging Cell
巻 16,
号 6,
p. 1288-1299,
発行日 2017-08-31
|
| 旧ID |
48594 |
AgingCell_16_1288.pdf (2.0 MB)
