{"created":"2025-02-21T01:52:37.624087+00:00","id":2005948,"links":{},"metadata":{"_buckets":{"deposit":"827ecb5b-0215-4b14-8f62-1641b826f5f3"},"_deposit":{"created_by":41,"id":"2005948","owner":"41","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2005948"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02005948","sets":["1730444908512:1730444916333"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"ヒト骨髄性白血病細胞株のフォルボールエステルによる分化誘導機構","subitem_title_language":"ja"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小田, 司","creatorNameLang":"ja"},{"creatorName":"Oda, Tsukasa","creatorNameLang":"en"}],"familyNames":[{"familyName":"小田","familyNameLang":"ja"},{"familyName":"Oda","familyNameLang":"en"}],"givenNames":[{"givenName":"司","givenNameLang":"ja"},{"givenName":"Tsukasa","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"Copyright(c) by Author"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"目次 / p1  略号 / p4  1.序言 / p1  　1.1 骨髄性白血病細胞とその分化誘導､及び本研究の目的 / p1  　1.2 分化誘導の分子機構に関する研究の歴史と現状 / p3  　1.3 骨髄性白血病細胞のフォルボールエステルによる分化誘導､増殖停止の可逆-非可逆性 / p6  　1.4 フォルボールエステル処理による骨髄性白血病細胞の増殖停止と分化形質発現の相関 / p7  　1.5 本研究の経緯､及び得られた結果の概要 / p8  2.細胞に強い親和性を示すフォルボールエステルPMA / p12  　2.1 はじめに / p12  　2.2 材料と方法 / p12  　2.3 結果と考察 / p16  3.HL-60細胞のフォルボールエステルによる分化誘導 / p34  I.分化状態の可逆性 / p34  　3.1 はじめに / p34  　3.2 材料と方法 / p34  　3.3 結果と考察 / p37  4.HL-60細胞のフォルボールエステルによる分化誘導 / p58  II 細胞増殖停止と分化形質発現の因果関係 / p58  　4.1 はじめに / p58  　4.2 材料と方法 / p59  　4.3 結果と考察 / p60  5.THP-1細胞のフォルボールエステルによる分化誘導 / p80  　5.1 はじめに / p80  　5.2 材料と方法 / p80  　5.3 結果と考察 / p82  6.本研究の結論および今後の展望 / p98  参考文献 / p101  謝辞 / p107","subitem_description_type":"TableOfContents"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_1617186819068":{"attribute_name":"Identifier Registration","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.11501/3071703","subitem_identifier_reg_type":"JaLC"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"1"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicPageStart":"1"}]},"item_1617187087799":{"attribute_name":"Dissertation Number","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第1172号"}]},"item_1617187112279":{"attribute_name":"Degree Name","attribute_value_mlt":[{"subitem_degreename":"博士(学術)","subitem_degreename_language":"ja"},{"subitem_degreename":"Science","subitem_degreename_language":"en"}]},"item_1617187136212":{"attribute_name":"Date Granted","attribute_value_mlt":[{"subitem_dategranted":"1993-03-25"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"diss_ko1172.pdf","filesize":[{"value":"45.1 MB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2005948/files/diss_ko1172.pdf"},"version_id":"9bf92a4b-179d-4da5-8271-2e36eb6a124a"}]},"item_1617944105607":{"attribute_name":"Degree Grantor","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"広島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"15401","subitem_degreegrantor_identifier_scheme":"kakenhi"}]},{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Hiroshima University"}]}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"31824"},"item_title":"ヒト骨髄性白血病細胞株のフォルボールエステルによる分化誘導機構","item_type_id":"40003","owner":"41","path":["1730444916333"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2005948","relation_version_is_last":true,"title":["ヒト骨髄性白血病細胞株のフォルボールエステルによる分化誘導機構"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-21T01:52:52.499812+00:00"}