{"created":"2025-02-21T01:44:14.165288+00:00","id":2005931,"links":{},"metadata":{"_buckets":{"deposit":"23ef0aea-23ce-4c14-98bf-0203143415f3"},"_deposit":{"created_by":41,"id":"2005931","owner":"41","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2005931"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02005931","sets":["1730444908512:1730444916333"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"薬物性肝障害モデルにおける弱塩基性薬物の体内動態変動の機序 : 血漿α[1]-Acid Glycoproteinの影響を中心として","subitem_title_language":"ja"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"杉原, 成美","creatorNameLang":"ja"},{"creatorName":"Sugihara, Narumi","creatorNameLang":"en"}],"familyNames":[{"familyName":"杉原","familyNameLang":"ja"},{"familyName":"Sugihara","familyNameLang":"en"}],"givenNames":[{"givenName":"成美","givenNameLang":"ja"},{"givenName":"Narumi","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"Copyright(c) by Author"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"目次  序論 / p1  本論 / p3  第1章 四塩化炭素肝障害モデルにおけるquinidineの体内動態 / p3  　第1節 単回静注投与後の血漿中挙動 / p3  　第2節 定常状態における組織分布 / p5  　第3節 全身クリアランス減少と肝機能低下の関連 / p10  　第4節 小括 / p12  第2章 四塩化炭素肝障害モデルにおけるquinidineの組織分布変動の機序 / p14  　第1節 組織分布の理論的解析 / p14  　第2節 組織結合 / p15  　第3節 血漿pHの測定 / p16  　第4節 血漿蛋白質結合 / p17  　第5節 小括 / p18  第3章 四塩化炭素肝障害モデルにおける弱塩基性薬物の血漿蛋白質結合率増大の要因 / p19  　第1節 In vitro血漿蛋白質結合 / p19  　第2節 血漿蛋白質結合に及ぼすTris(butoxyethyl)-phosphateの影響 / p20  　第3節 血漿蛋白質濃度の測定 / p22  　第4節 血漿蛋白質結合率と血漿α₁-acid glycoprotein濃度の相関 / p23  　第5節 小括 / p24  第4章 種々の薬物性肝障害モデルにおける弱塩基性薬物の血漿蛋白質結合 / p25  　第1節 血漿蛋白質濃度の測定 / p25  　第2節 肝障害度と血漿α₁-acid glycoprotein濃度の関係 / p28  　第3節 血漿蛋白質結合率と血漿α₁-acid glycoprotein濃度との相関 / p30  　第4節 小括 / p32  第5章 高α₁-acid glycoprotein血漿モデル(テレビン油投与ラット)におけるquinidineの体内動態 / p33  　第1節 生理学的パラメーター / p33  　第2節 単回静注投与後の血漿中挙動 / p35  　第3節 肝抽出率の測定 / p38  　第4節 組織分布と血漿蛋白質結合率との相関 / p40  　第5節 小括 / p42  第6章 結論 / p44  謝辞 / p46  論文目録 / p47  実験の部 / p48  引用文献 / p61","subitem_description_type":"TableOfContents"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_1617186819068":{"attribute_name":"Identifier Registration","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.11501/3071725","subitem_identifier_reg_type":"JaLC"}]},"item_1617187024783":{"attribute_name":"Page Start","attribute_value_mlt":[{"subitem_start_page":"1"}]},"item_1617187056579":{"attribute_name":"Bibliographic Information","attribute_value_mlt":[{"bibliographicPageStart":"1"}]},"item_1617187087799":{"attribute_name":"Dissertation Number","attribute_value_mlt":[{"subitem_dissertationnumber":"乙第2334号"}]},"item_1617187112279":{"attribute_name":"Degree Name","attribute_value_mlt":[{"subitem_degreename":"博士(薬学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Pharmacology","subitem_degreename_language":"en"}]},"item_1617187136212":{"attribute_name":"Date Granted","attribute_value_mlt":[{"subitem_dategranted":"1992-11-26"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"1. Narumi SUGIHARA, Koji FURUNO, Noriko KITA, Teruo MURAHANI, Noboru YATA: \"Distribution of Quinidine in Rats with Carbon Tetrachloride-Intoxicated Hepatic Disease.\" J. Pharmacobio-Dyn., 15, 167-174 (1992)."}],"subitem_relation_type":"references"},{"subitem_relation_name":[{"subitem_relation_name_text":"2. Narumi SUGIHARA, Koji FURUNO, Noriko HITA, Teruo MURAHANI, Noboru YATA: \"Increase in the Plasmpa Protein Binding of Weakly Basic Drugs in Carbon Tetrachloride-Intoxicated Rats.\" Chem. Pharm. Bull., 39, 2671-2673 (1991)."}],"subitem_relation_type":"references"},{"subitem_relation_name":[{"subitem_relation_name_text":"3. Narumi SUGIHARA, Koji FURUNO, Noriko KITA, Teruo NURAHAMI, Noboru YATA: \"Plasma α1-Acid Glycoprotein Concentration in Rats with Chemical Liver Injury.\" Chem. Pharm. Bull., 40, 2516-2519 (1992)."}],"subitem_relation_type":"references"},{"subitem_relation_name":[{"subitem_relation_name_text":"4. Narumi SUGIHARA, Koji FURUNO, Noriko HITA, Teruo MURAKAMI, Noboru YATA: \"The Influence of Increased Plasma Protein Binding on the Disposition of Quinidine in Turpentine-Treated Rats.\" Biol. Pharm. Bull., 16, No.1 (1993)."}],"subitem_relation_type":"references"},{"subitem_relation_type":"references","subitem_relation_type_id":{"subitem_relation_type_id_text":"110003637540","subitem_relation_type_select":"NAID"}},{"subitem_relation_type":"references","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1248/cpb.39.2671","subitem_relation_type_select":"DOI"}},{"subitem_relation_type":"references","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1248/cpb.40.2516","subitem_relation_type_select":"DOI"}},{"subitem_relation_type":"references","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1248/bpb.16.63","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-18"}],"displaytype":"simple","filename":"diss_otsu2334.pdf","filesize":[{"value":"25.7 MB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2005931/files/diss_otsu2334.pdf"},"version_id":"174d1a36-7d81-4ae1-89ef-5e8c56eac194"}]},"item_1617944105607":{"attribute_name":"Degree Grantor","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"広島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"15401","subitem_degreegrantor_identifier_scheme":"kakenhi"}]},{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Hiroshima University"}]}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"31827"},"item_title":"薬物性肝障害モデルにおける弱塩基性薬物の体内動態変動の機序 : 血漿α[1]-Acid Glycoproteinの影響を中心として","item_type_id":"40003","owner":"41","path":["1730444916333"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-03-18"},"publish_date":"2023-03-18","publish_status":"0","recid":"2005931","relation_version_is_last":true,"title":["薬物性肝障害モデルにおける弱塩基性薬物の体内動態変動の機序 : 血漿α[1]-Acid Glycoproteinの影響を中心として"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-21T01:44:28.338023+00:00"}