{"created":"2025-02-18T10:04:01.204795+00:00","id":2005194,"links":{},"metadata":{"_buckets":{"deposit":"35307796-6e83-4edd-bb28-30f06452d2c5"},"_deposit":{"created_by":41,"id":"2005194","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2005194"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02005194","sets":["1730444908512:1730444915582"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Association between serum levels of n-3 polyunsaturated fatty acids and coronary plaque detected by coronary computed tomography angiography in patients receiving statin therapy","subitem_title_language":"en"},{"subitem_title":"スタチン治療患者における血清n-3系多価不飽和脂肪酸濃度と冠動脈プラークとの関連性 : 冠動脈CT血管造影による評価","subitem_title_language":"ja"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"卜部, 洋司","creatorNameLang":"ja"},{"creatorName":"Urabe, Youji","creatorNameLang":"en"}],"familyNames":[{"familyName":"卜部","familyNameLang":"ja"},{"familyName":"Urabe","familyNameLang":"en"}],"givenNames":[{"givenName":"洋司","givenNameLang":"ja"},{"givenName":"Youji","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"Copyright(c) by Author"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"Coronary computed tomography angiography","subitem_subject_scheme":"Other"},{"subitem_subject":"Coronary plaques","subitem_subject_scheme":"Other"},{"subitem_subject":"Eicosapentaenoic acid","subitem_subject_scheme":"Other"},{"subitem_subject":"N-3 polyunsaturated fatty acid","subitem_subject_scheme":"Other"},{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Background: Intensive lipid-lowering therapy with statins reduces cardiovascular events, but residual cardiovascular risks remain. Intake of n-3 polyunsaturated fatty acids (PUFAs) has been associated with cardiovascular events. We examined the relationships between serum n-3 PUFAs and coronary atherosclerotic findings on computed tomography angiography (CTA) in patients undergoing statin treatment.      Methods and Results: We enrolled 172 subjects (mean age: 68.2 years; 64% men) prior to statin treatment for 6 months. Serum PUFAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and arachidonic acid, were measured. When the patients were divided into 2 groups according to the median EPA level (61.3 μg/ml), the low-EPA group showed higher incidences of 3-vessel plaque involvement (62% vs. 43%, P=0.015), noncalcified plaques (NCPs) (74% vs. 52%, P=0.0016), extensive NCPs (?2 segments) (56% vs. 34%, P=0.0036), and high-risk plaques (minimum CT density <39 HU and remodeling index >1.05) (43% vs. 22%, P=0.0034). Multivariate analyses revealed that low EPA levels were an independent factor for these coronary plaque findings. The DHA levels were not independently associated with these findings.      Conclusions: Low serum EPA level, but not serum DHA, is associated with the presence and extent of NCPs and high-risk plaques detected by coronary CTA in patients undergoing lipid-lowering therapy with statins.","subitem_description_language":"en"}]},"item_1617186660861":{"attribute_name":"Date","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-11-21","subitem_date_issued_type":"Created"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617187087799":{"attribute_name":"Dissertation Number","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第6392号"}]},"item_1617187112279":{"attribute_name":"Degree Name","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_1617187136212":{"attribute_name":"Date Granted","attribute_value_mlt":[{"subitem_dategranted":"2014-03-23"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Yoji Urabe, Hideya Yamamoto, Toshiro Kitagawa, Hiroto Utsunomiya, Hiroshi Tsushima, Fuminari Tatsugami, Kazuo Awai and Yasuki Kihara; Association Between Serum Levels of n-3 Polyunsaturated Fatty Acids and Coronary Plaque Detected by Coronary Computed Tomography Angiography in Patients Receiving Statin Therapy; Circulation Journal Vol. 77 (2013) No. 10 2578-2585 (doi: 10.1253/circj.CJ-13-0257) "}],"subitem_relation_type":"references"},{"subitem_relation_type":"references","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1253/circj.CJ-13-0257","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2014-11-21"}],"displaytype":"simple","filename":"k6392_3.pdf","filesize":[{"value":"1.2 MB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2005194/files/k6392_3.pdf"},"version_id":"1a367e4d-724e-404f-8a84-39039d709006"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2014-11-21"}],"displaytype":"simple","filename":"k6392_1.pdf","filesize":[{"value":"297.7 KB"}],"mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://hiroshima.repo.nii.ac.jp/record/2005194/files/k6392_1.pdf"},"version_id":"0dba624f-1835-4610-893f-b6aefa1eac05"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2014-11-21"}],"displaytype":"simple","filename":"k6392_2.pdf","filesize":[{"value":"195.2 KB"}],"mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://hiroshima.repo.nii.ac.jp/record/2005194/files/k6392_2.pdf"},"version_id":"9f59438e-7edf-4f5f-a0c4-df2681a64ec6"}]},"item_1617944105607":{"attribute_name":"Degree Grantor","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"広島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"15401","subitem_degreegrantor_identifier_scheme":"kakenhi"}]},{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Hiroshima University"}]}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"36307"},"item_title":"Association between serum levels of n-3 polyunsaturated fatty acids and coronary plaque detected by coronary computed tomography angiography in patients receiving statin therapy","item_type_id":"40003","owner":"41","path":["1730444915582"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-11-21"},"publish_date":"2014-11-21","publish_status":"0","recid":"2005194","relation_version_is_last":true,"title":["Association between serum levels of n-3 polyunsaturated fatty acids and coronary plaque detected by coronary computed tomography angiography in patients receiving statin therapy"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-20T07:45:38.152734+00:00"}