{"created":"2025-02-18T10:00:17.230470+00:00","id":2005064,"links":{},"metadata":{"_buckets":{"deposit":"d6a12081-e7c9-429e-8147-31889b753c25"},"_deposit":{"created_by":41,"id":"2005064","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2005064"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02005064","sets":["1730444908512:1730444915582"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Low high density lipoprotein cholesterol level is a significant risk factor for development of type 2 diabetes : Data from the Hawaii-Los Angeles-Hiroshima study","subitem_title_language":"en"},{"subitem_title":"低HDLコレステロール値は、2型糖尿病発症の危険因子である : ハワイ・ロサンゼルス・広島スタディより","subitem_title_language":"ja"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"平野, 雅俊","creatorNameLang":"ja"},{"creatorName":"Hirano, Masatoshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"平野","familyNameLang":"ja"},{"familyName":"Hirano","familyNameLang":"en"}],"givenNames":[{"givenName":"雅俊","givenNameLang":"ja"},{"givenName":"Masatoshi","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"Copyright(c) by Author"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"High-density lipoprotein cholesterol","subitem_subject_scheme":"Other"},{"subitem_subject":"Type 2 diabetes","subitem_subject_scheme":"Other"},{"subitem_subject":"Westernized lifestyle","subitem_subject_scheme":"Other"},{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Aims/Introduction: A low level of high-density lipoprotein cholesterol (HDLC) is a common feature of metabolic syndrome. We have reported that Japanese-Americans who share a virtually identical genetic makeup with native Japanese, but who have lived Westernized lifestyles for decades, have lower HDLC levels and a high prevalence of type 2 diabetes compared with native Japanese. However, the impact of low HDLC level on type 2 diabetes is unclear. The aims of the present study were to evaluate whether serum HDLC level was associated with development of type 2 diabetes and if the effect might be modified by lifestyle.      Materials and Methods: We examined 1,133 non-diabetic Japanese-Americans and 1,072 non-diabetic Japanese, who underwent the 75-g oral glucose tolerance test (OGTT) and were followed for an average of 8.8 and 7.0 years, respectively. We analyzed whether serum HDLC level is a risk factor for development of type 2 diabetes based on the Cox proportional hazards model.      Results: After adjustment for age and sex, hazard ratios for development of type 2 diabetes per unit of serum HDLC level (mmol/L) were 0.292 (95% confidence interval [CI] 0.186-0.458, P < 0.0001) among Japanese-Americans and 0.551 (95% CI 0.375-0.88, P = 0.0023) among native Japanese. Comparable hazard ratios after further adjustment for category of OGTT and body mass index were 0.981 (95% CI 0.970-0.993, P = 0.0018) and 0.991 (95% CI 0.980-1.002, P = 0.112), respectively.      Conclusions: HDLC level was associated with development of type 2 diabetes in both Japanese-Americans and native Japanese. However, these results suggest that the impact of high-density lipoprotein on glucose metabolism might be affected by lifestyle.","subitem_description_language":"en"}]},"item_1617186660861":{"attribute_name":"Date","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-11-21","subitem_date_issued_type":"Created"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617187087799":{"attribute_name":"Dissertation Number","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第6278号"}]},"item_1617187112279":{"attribute_name":"Degree Name","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Philosophy in Medical Science","subitem_degreename_language":"en"}]},"item_1617187136212":{"attribute_name":"Date Granted","attribute_value_mlt":[{"subitem_dategranted":"2014-01-23"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Masatoshi Hirano, Shuhei Nakanishi, Mitsunobu Kubota, Shusaku Maeda, Masayasu Yoneda, Kiminori Yamane, Sakurako Kira, Hideo Sasaki and Nobuoki Kohno; Low high-density lipoprotein cholesterol level is a significant risk factor for development of type 2 diabetes: Data from the Hawaii-Los Angeles-Hiroshima study; Journal of Diabetes Investigation, 2013 (doi: 10.1111/jdi.12170) "}],"subitem_relation_type":"references"},{"subitem_relation_type":"references","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1111/jdi.12170","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2014-11-21"}],"displaytype":"simple","filename":"k6278_3.pdf","filesize":[{"value":"124.4 KB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2005064/files/k6278_3.pdf"},"version_id":"a779fbbe-9be1-4045-831b-c86ba21fab95"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2014-11-21"}],"displaytype":"simple","filename":"k6278_1.pdf","filesize":[{"value":"302.0 KB"}],"mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://hiroshima.repo.nii.ac.jp/record/2005064/files/k6278_1.pdf"},"version_id":"9408729b-7d04-4bbd-980a-39433550762b"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2014-11-21"}],"displaytype":"simple","filename":"k6278_2.pdf","filesize":[{"value":"167.3 KB"}],"mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://hiroshima.repo.nii.ac.jp/record/2005064/files/k6278_2.pdf"},"version_id":"93fb79ce-dd80-4aac-9802-68d441130977"}]},"item_1617944105607":{"attribute_name":"Degree Grantor","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"広島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"15401","subitem_degreegrantor_identifier_scheme":"kakenhi"}]},{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Hiroshima University"}]}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"36282"},"item_title":"Low high density lipoprotein cholesterol level is a significant risk factor for development of type 2 diabetes : Data from the Hawaii-Los Angeles-Hiroshima study","item_type_id":"40003","owner":"41","path":["1730444915582"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-11-21"},"publish_date":"2014-11-21","publish_status":"0","recid":"2005064","relation_version_is_last":true,"title":["Low high density lipoprotein cholesterol level is a significant risk factor for development of type 2 diabetes : Data from the Hawaii-Los Angeles-Hiroshima study"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-20T07:26:44.547588+00:00"}