{"created":"2025-02-18T09:59:20.709498+00:00","id":2005031,"links":{},"metadata":{"_buckets":{"deposit":"2895d2f8-3c9f-44f0-ab6e-a65cef0c05b4"},"_deposit":{"created_by":41,"id":"2005031","owners":[41],"pid":{"revision_id":0,"type":"depid","value":"2005031"},"status":"published"},"_oai":{"id":"oai:hiroshima.repo.nii.ac.jp:02005031","sets":["1730444908512:1730444915582"]},"author_link":[],"item_1617186331708":{"attribute_name":"Title","attribute_value_mlt":[{"subitem_title":"Aurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis","subitem_title_language":"en"},{"subitem_title":"Aurora-A は細胞分裂期においてgeminin を安定化することで複製前複合体形成やDNA複製を制御する","subitem_title_language":"ja"}]},"item_1617186419668":{"attribute_name":"Creator","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"常松, 貴明","creatorNameLang":"ja"},{"creatorName":"Tsunematsu, Takaaki","creatorNameLang":"en"}],"familyNames":[{"familyName":"常松","familyNameLang":"ja"},{"familyName":"Tsunematsu","familyNameLang":"en"}],"givenNames":[{"givenName":"貴明","givenNameLang":"ja"},{"givenName":"Takaaki","givenNameLang":"en"}]}]},"item_1617186476635":{"attribute_name":"Access Rights","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1617186499011":{"attribute_name":"Rights","attribute_value_mlt":[{"subitem_rights":"Copyright(c) by Author"}]},"item_1617186609386":{"attribute_name":"Subject","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_1617186626617":{"attribute_name":"Description","attribute_value_mlt":[{"subitem_description":"Geminin, an essential factor for DNA replication, directly binds to the licensing factor Cdt1 and inhibits pre-replicative complex (pre-RC) formation to prevent re-replication. In G1, geminin levels are controlled by the anaphase-promoting complex/cyclosome ubiquitin ligase complex (APC/C), which targets geminin for proteasomal degradation to allow pre-RC formation. Conversely, from S to G2, geminin is stabilized thanks to APC/C inhibition to ensure inhibition of pre-RC formation. However, mitotic regulation of geminin has hitherto not been described. Here we show that Aurora-A phosphorylates geminin on Thr25 during M phase, and this event induces geminin stabilization by preventing its APC/C-mediated degradation during mitosis. In turn, stabilized geminin inhibits SCFSkp2-mediated degradation of Cdt1 to ensure pre-RC formation in the ensuing S phase. The Aurora-A-geminin-Cdt1 axis therefore represents a critical regulator of proper DNA replication.","subitem_description_language":"en"}]},"item_1617186660861":{"attribute_name":"Date","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014-11-21","subitem_date_issued_type":"Created"}]},"item_1617186702042":{"attribute_name":"Language","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_1617187087799":{"attribute_name":"Dissertation Number","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第6249号"}]},"item_1617187112279":{"attribute_name":"Degree Name","attribute_value_mlt":[{"subitem_degreename":"博士(歯学)","subitem_degreename_language":"ja"},{"subitem_degreename":"Philosophy in Dental Science","subitem_degreename_language":"en"}]},"item_1617187136212":{"attribute_name":"Date Granted","attribute_value_mlt":[{"subitem_dategranted":"2013-09-25"}]},"item_1617258105262":{"attribute_name":"Resource Type","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_1617265215918":{"attribute_name":"Version Type","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1617353299429":{"attribute_name":"Relation","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Takaaki Tsunematsu, Yoshihiro Takihara, Naozumi Ishimaru, Michele Pagano, Takashi Takata & Yasusei Kudo; Aurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis; Nature Communications Volume 4, Article number 1885 (doi: 10.1038/ncomms2859) "}],"subitem_relation_type":"references"},{"subitem_relation_type":"references","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1038/ncomms2859","subitem_relation_type_select":"DOI"}}]},"item_1617605131499":{"attribute_name":"File","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2014-11-21"}],"displaytype":"simple","filename":"k6249_3.pdf","filesize":[{"value":"2.6 MB"}],"mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://hiroshima.repo.nii.ac.jp/record/2005031/files/k6249_3.pdf"},"version_id":"140f520b-f8e6-40ad-9ab1-3f3500194e50"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2014-11-21"}],"displaytype":"simple","filename":"k6249_1.pdf","filesize":[{"value":"169.2 KB"}],"mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://hiroshima.repo.nii.ac.jp/record/2005031/files/k6249_1.pdf"},"version_id":"c64f2e4d-70e8-4645-acfe-4855a830c762"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2014-11-21"}],"displaytype":"simple","filename":"k6249_2.pdf","filesize":[{"value":"163.8 KB"}],"mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://hiroshima.repo.nii.ac.jp/record/2005031/files/k6249_2.pdf"},"version_id":"23c1c5ba-d981-4775-9c98-6fc8d114ce91"}]},"item_1617944105607":{"attribute_name":"Degree Grantor","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"広島大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"15401","subitem_degreegrantor_identifier_scheme":"kakenhi"}]},{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"en","subitem_degreegrantor_name":"Hiroshima University"}]}]},"item_1732771732025":{"attribute_name":"旧ID","attribute_value":"36273"},"item_title":"Aurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis","item_type_id":"40003","owner":"41","path":["1730444915582"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-11-21"},"publish_date":"2014-11-21","publish_status":"0","recid":"2005031","relation_version_is_last":true,"title":["Aurora-A controls pre-replicative complex assembly and DNA replication by stabilizing geminin in mitosis"],"weko_creator_id":"41","weko_shared_id":-1},"updated":"2025-02-20T07:22:15.626522+00:00"}