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アイテム
腹部大動脈瘤形成における、平滑筋細胞でのTimp1遺伝子誘導
https://hiroshima.repo.nii.ac.jp/records/2005028
https://hiroshima.repo.nii.ac.jp/records/2005028f5f43b65-72ef-4e32-9e2d-5385745b626a
| 名前 / ファイル | ライセンス | アクション |
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k6246_3.pdf (540.2 KB)
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k6246_1.pdf (231.3 KB)
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k6246_2.pdf (154.5 KB)
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| Item type | デフォルトアイテムタイプ_（フル）(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2014-11-25 | |||||||
| タイトル | ||||||||
| タイトル | Induction of Timp1 in Smooth Muscle Cells during Development of Abdominal Aortic Aneurysms | |||||||
| 言語 | en | |||||||
| タイトル | ||||||||
| タイトル | 腹部大動脈瘤形成における、平滑筋細胞でのTimp1遺伝子誘導 | |||||||
| 言語 | ja | |||||||
| 作成者 |
Bumdelger, Batmunkh
× Bumdelger, Batmunkh
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| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Abdominal aortic aneurysm | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Mmp9 | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | Timp1 | |||||||
| 主題 | ||||||||
| 主題Scheme | Other | |||||||
| 主題 | TNF-α | |||||||
| 主題 | ||||||||
| 主題Scheme | NDC | |||||||
| 主題 | 490 | |||||||
| 内容記述 | ||||||||
| 内容記述 | Abdominal aortic aneurysm (AAA) is known to develop mainly by the increased diameter of aorta through metalloproteinases (MMPs). Although activities of MMPs are tightly regulated by the presence of tissue inhibitor of MMPs (TIMPs) and imbalances between MMPs and TIMPs may serve to fragility of arterial wall, little is known about TIMPs behavior in aneurysmal formation. Here, we utilized a murine experimental AAA model, and found that by immunohistochemical analysis, Timp1 as and Timp1 mRNA levels was also revealed in aortic tissue in AAA by RT-PCR. In cultured vascular smooth muscle cells (SMCs), Tumor Necrosis Factor (TNF)-α significantly activated both Mmp9 and Timp1 expression, and they were blocked by Jun kinase inhibitor (SP600125) in a dose-dependent manner. Interestingly, a proteasome inhibitor (MG132), which is known as an agent for inhibition of the nuclear factor-kappa B (NF-kB), significantly inhibited the TNF-α-induced expression of Timp1, whereas MG132, which also works as an activator of c-Jun/AP-1 pathway, strongly increased Mmp9. Taken together, inflammatory cytokines, including TNF-α, may simultaneously induce MMPs and TIMPs for the remodeling of the medial layer, leading to the increased diameter of the aorta, the aneurysm. | |||||||
| 言語 | en | |||||||
| 日付 | ||||||||
| 日付 | 2014-11-25 | |||||||
| 日付タイプ | Created | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||||
| 資源タイプ | doctoral thesis | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | NA | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||||
| 関連情報 | ||||||||
| 関連タイプ | references | |||||||
| 関連名称 | Batmunkh Bumdelger, Hiroki Kokubo, Ryo Kamata, Masayuki Fujii, Mari Ishida, Takafumi Ishida and Masao Yoshizumi; Induction of Timp1 in Smooth Muscle Cells during Development of Abdominal Aortic Aneurysms; Hiroshima J. Med. Sci. Vol.62, No.3, 63-67, September, 2013 | |||||||
| 学位授与番号 | ||||||||
| 学位授与番号 | 甲第6246号 | |||||||
| 学位名 | ||||||||
| 言語 | ja | |||||||
| 学位名 | 博士(医学) | |||||||
| 学位名 | ||||||||
| 言語 | en | |||||||
| 学位名 | Philosophy in Medical Science | |||||||
| 学位授与年月日 | ||||||||
| 学位授与年月日 | 2013-09-25 | |||||||
| 学位授与機関 | ||||||||
| 学位授与機関識別子Scheme | kakenhi | |||||||
| 学位授与機関識別子 | 15401 | |||||||
| 言語 | ja | |||||||
| 学位授与機関名 | 広島大学 | |||||||
| 学位授与機関 | ||||||||
| 言語 | en | |||||||
| 学位授与機関名 | Hiroshima University | |||||||
| 旧ID | 36323 | |||||||
