2026-03-13T13:33:34Z https://hiroshima.repo.nii.ac.jp/oai

oai:hiroshima.repo.nii.ac.jp:02007118 2025-02-21T09:09:06Z 1730444907710

Titanium Immobilized with an Antimicrobial Peptide Derived from Histatin Accelerates the Differentiation of Osteoblastic Cell Line, MC3T3-E1 Makihira, Seicho Shuto, Takahiro Nikawa, Hiroki Okamoto, Keishi Mine, Yuichi Takamoto, Yuko Ohara, Masaru Tsuji, Koichiro antimicrobial peptide titanium surface MC3T3-E1 cells 490 The objective of this study was to evaluate the effect of titanium immobilized with a cationic antimicrobial peptide (JH8194) derived from histatin on the biofilm formation of Porphyromonas gingivalis and differentiation of osteoblastic cells (MC3T3-E1). The titanium specimens (Ti) were immobilized with JH8194, according to the method previously described. The colonization of P. gingivalis on JH8194-Ti was significantly lower than that on control- and blocking-Ti. JH8194-Ti enhanced the mRNA expressions of Runx2 and OPN, and ALPase activity in the MC3T3-E1, as compared with those of control- and blocking-Ti. These results, taken together, suggested the possibility that JH8194-Ti may be a potential aid to shorten the period of acquiring osseointegration. http://purl.org/coar/resource_type/c_6501 Molecular Diversity Preservation International-MDPI 2010-04-02 VoR 1422-0067 AA12038549 1458 International Journal of Molecular Sciences 4 11 1470 1458 International Journal of Molecular Sciences https://hiroshima.repo.nii.ac.jp/records/2007118 eng 10.3390/ijms11041458 http://dx.doi.org/10.3390/ijms11041458 open access Copyright (c) 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.