2026-03-13T20:45:35Z https://hiroshima.repo.nii.ac.jp/oai

oai:hiroshima.repo.nii.ac.jp:02006127 2025-04-30T00:20:40Z 1730444907710

Controlling the Magnetic Responsiveness of Cellulose Nanofiber Particles Embedded with Iron Oxide Nanoparticles Bahri, Nur Syakirah Nabilah Saipul Nguyen, Tue Tri Matsumoto, Kohei Watanabe, Mai Morita, Yuko Eka, Lutfi Septiani Cao, Le Anh Kiet Hirano, Tomoyuki Ogi, Takashi TEMPO-Oxidized Cellulose Nanofibers Iron Oxide Nanoparticles Nanostructured Material Spray Drying Functionalized Composite Particles Magnetic Separation Streptavidin-biotin Binding Biomedical Application 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofiber (TOCN) particles, an innovative biobased material derived from wood biomass, have garnered significant interest, particularly in the biomedical field, for their distinctive properties as biocompatible particle adsorbents. However, their microscopic size complicates their separation in liquid media, thereby impeding their application in various domains. In this study, superparamagnetic magnetite nanoparticles (NPs), specifically iron oxide Fe3O4 NPs with an average size of 15 nm, were used to enhance the collection efficiency of TOCN-Fe3O4 composite particles synthesized through spray drying. These composite particles exhibited a remarkable ζ-potential (approximately −50 mV), indicating their high stability in water, as well as impressive magnetization properties (up to 47 emu/g), and rapid magnetic responsiveness within 60 s in water (3 wt % Fe3O4 to TOCN, 1 T magnet). Furthermore, the influence of Fe3O4 NP concentrations on the measurement of the speed of magnetic separation was quantitatively discussed. Additionally, the binding affinity of the synthesized particles for proteins was assessed on a streptavidin–biotin binding system, offering crucial insights into their binding capabilities with specific proteins and underscoring their significant potential as functionalized biomedical materials. http://purl.org/coar/resource_type/c_6501 American Chemical Society 2024-04-16 AM 3227 ACS Applied Bio Materials 5 7 3237 3227 https://hiroshima.repo.nii.ac.jp/records/2006127 eng https://doi.org/10.1021/acsabm.4c00213 open access This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Bio Materials, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsabm.4c00213 This is not the published version. Please cite only the published version. この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。