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oai:hiroshima.repo.nii.ac.jp:02006031 2025-02-21T02:31:44Z 1730444908512:1730444916333

Effect of N-feruloyl tyramine (an analogue of tyramine) on inwardly rectifying potassium channel in frog ventricular myocytes チラミン類縁体N-フェルロイルチラミンによるカエル心室筋内向き整流性カリウムチャンネルに対する影響 宗盛, 真 Munemori, Makoto NFT iK1 Suppression 490 Electrophysiological effects of N-feruloyl tyramine (NFT), an analogue of tyramine, on potassium currents in frog ventricular myocytes were examined using single-channel recording and whole-cell voltage clamp technique. Extracellular application of NFT induced a concentration-dependent decrease of macroscopic inward rectifier potassium current (iK1) with ID50 of 198 ,#uM, while tyramine (100 #M) was ineffective in producing an inhibitory effect on iK1. NFT reduced the mean open time of iK1 to 1.3 ms from 3.1 ms in control without affecting the amplitude of single-channel conductance. It is indicated that boi containing NFT produces a prolongation of the plateau phase caused by the suppression of inwardly rectifying K channel. Thus, this prolongation may induce an increase in the inflow of Ca ions, which in turn leads to a positive inotropic effect. 博士(医学) Medicine http://purl.org/coar/resource_type/c_db06 広島大学 Hiroshima University 1996-03-26 NA 1 1 甲第1484号 https://doi.org/10.11501/3119814 https://hiroshima.repo.nii.ac.jp/records/2006031 eng Hiroshima J. Med. Sci. Vol.45, No.1, 31-35, March, 1996. HIJM45-5 8984103 open access Copyright(c) by Author