2026-03-15T01:29:48Z https://hiroshima.repo.nii.ac.jp/oai

oai:hiroshima.repo.nii.ac.jp:02013239 2025-06-02T03:00:55Z 1727147343679:1730442224523:1730442325010

A Pharmacological Study of Veratrine-Induced Hyperthermia in the Rat : A Model of Neuroleptic Malignant Syndrome Kato, Tadahiro Kato Tadahiro Yamawaki, Shigeto Yamawaki Shigeto open access Dopamine Serotonin Veratrine Neuroleptic malignant syndmme 490 Stereotaxic microinjection of veratrine (50 μg in 1 μl of saline) into the preoptic anterior hypothalamus of rats which were intraperitoneally pretreated with haloperidol (1 mg/kg), significantly elevated body temperature (1.4 °C above normal body temperature) and produced abnormal behaviors. This microinjection also facilitated turnover of dopamine and serotonin in the regions of the thalamus and hypothalamus. Hyperthermia induced by haloperidol plus veratrine was significantly inhibited by systemic administration of serotonin antagonists (cyproheptadine 10 mg/kg, ritanserin 3 mg/kg). These findings suggest that hyperthermia in neuroleptic malignant syndrome is due to the dominant effect of serotonin in the thermoregulatory center either by blocking the dopamine receptor or by enhancing the serotonin secretion. Hiroshima University Medical Press 1989-12 eng departmental bulletin paper VoR https://hiroshima.repo.nii.ac.jp/records/2013239 2637245 0018-2052 AA00664312 Hiroshima Journal of Medical Sciences Hiroshima Journal of Medical Sciences 38 4 173 173 181 https://hiroshima.repo.nii.ac.jp/record/2013239/files/HiroshimaJMedSci_38_173.pdf 454.1 KB