2026-03-15T23:43:18Z https://hiroshima.repo.nii.ac.jp/oai

oai:hiroshima.repo.nii.ac.jp:02013047 2025-06-02T02:55:36Z 1727147343679:1730442224523:1730442335705

Two Cases of Dizygotic Twins with Androgenetic Mole and Normal Conceptus OHAMA, Koso OHAMA Koso UEDA, Katsunori UEDA Katsunori OKAMOTO, Etsuji OKAMOTO Etsuji FUJIWARA, Atsushi FUJIWARA Atsushi open access Twin pregnancy Androgenetic mole Malignant trophoblastic disease Ovulation induction therapy 490 Two cases showing a molar placenta with a fetus/infant were analyzed for karyotype and enzyme polymorphisms and found to be dizygotic twin pregnancies with an androgenetic mole and a normal conceptus. One case resulted in spontaneous abortion at 19 weeks' gestation and was subsequently diagnosed as an invasive mole and required chemotherapy. The other case was a conception following clomiphene plus human menopausal gonadotropin (HMG) therapy and resulted in a normal female infant born at 33 weeks. It is emphasized that, since dizygotic twins in which one is an androgenetic mole have a high propensity for malignancy, they should be carefully differentiated from partial moles with which they might be confused by analysis of genetic polymorphisms and they should be followed up with care. Hiroshima University School of Medicine 1985-12 eng departmental bulletin paper VoR https://hiroshima.repo.nii.ac.jp/records/2013047 3913657 0018-2052 AA00664312 Hiroshima Journal of Medical Sciences Hiroshima Journal of Medical Sciences 34 4 371 371 375 https://hiroshima.repo.nii.ac.jp/record/2013047/files/HiroshimaJMedSci_34_371.pdf 594.1 KB