2026-03-12T10:40:52Z https://hiroshima.repo.nii.ac.jp/oai

oai:hiroshima.repo.nii.ac.jp:02007118 2025-02-21T09:09:06Z 1730444907710

Titanium Immobilized with an Antimicrobial Peptide Derived from Histatin Accelerates the Differentiation of Osteoblastic Cell Line, MC3T3-E1 Makihira, Seicho Makihira Seicho Shuto, Takahiro Shuto Takahiro Nikawa, Hiroki Nikawa Hiroki Okamoto, Keishi Okamoto Keishi Mine, Yuichi Mine Yuichi Takamoto, Yuko Takamoto Yuko Ohara, Masaru Ohara Masaru Tsuji, Koichiro Tsuji Koichiro open access Copyright (c) 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. antimicrobial peptide titanium surface MC3T3-E1 cells 490 The objective of this study was to evaluate the effect of titanium immobilized with a cationic antimicrobial peptide (JH8194) derived from histatin on the biofilm formation of Porphyromonas gingivalis and differentiation of osteoblastic cells (MC3T3-E1). The titanium specimens (Ti) were immobilized with JH8194, according to the method previously described. The colonization of P. gingivalis on JH8194-Ti was significantly lower than that on control- and blocking-Ti. JH8194-Ti enhanced the mRNA expressions of Runx2 and OPN, and ALPase activity in the MC3T3-E1, as compared with those of control- and blocking-Ti. These results, taken together, suggested the possibility that JH8194-Ti may be a potential aid to shorten the period of acquiring osseointegration. Molecular Diversity Preservation International-MDPI 2010-04-02 eng journal article VoR https://hiroshima.repo.nii.ac.jp/records/2007118 10.3390/ijms11041458 http://dx.doi.org/10.3390/ijms11041458 1422-0067 AA12038549 International Journal of Molecular Sciences International Journal of Molecular Sciences 11 4 1458 1458 1470 https://hiroshima.repo.nii.ac.jp/record/2007118/files/IntJMolSci_11_1458.pdf 379.9 KB