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Structure-Activity Correlationship and Strain Specificity of Polyoxometalates in Anti-human Immunodeficiency Virus Activity Inoue, Yoshio Inoue Yoshio Fujimoto, Yasuhiro Fujimoto Yasuhiro Sugiyama, Masanori Sugiyama Masanori Yoshida, Tetsuya Yoshida Tetsuya Yamase, Toshihiro Yamase Toshihiro open access © 1995 Pharmaceutical Society of Japan polyoxometalate human immunodeficiency virus strain specificity syncytium formation cytopathogenicity 490 The anti-human immunodeficiency virus (HIV) activity of polyoxometalates of representative structural families, such as Keggin, lacunary Keggin, trivacant Keggin, Keggin sandwich, Wells-Dawson and Wells-Dawson sandwich, was determined using two strains of HIV type 1 (HIV-1HTLV-IIIBand HIV-1SF-2H). The compounds were preferably selected to cover both polyoxotungstates and polyoxomolybdates in each structural family. In general, polyoxotungstates of Keggin, lacumary Keggin, trivacant Keggin, Keggin sandwich, Wells-Dawson and Wells-Dawson sandwich structures showed anti-HIV-1HTLV-IIIBactivity, whereas most compounds not included in these structural categories were inactive. Among the compounds with a potent anti-HIV-1HTLV-IIIBactivity, those of Keggin and its closely related structural families (lacunary Keggin, trivacant Keggin and Keggin sandwich) inhibited the cytopathogenicity and syncytium formation caused by HIV-1SF-2Hto a much higher extent compared with HIV-1HTLV-IIIB-related ones. The difference between the spectra of anti-HIV-1HTLV-IIIBactivity and the specificity for HIV-1SF-2Hmight result from differential structural requirements in these functions. The Pharmaceutical Society of Japan 1995-07-15 eng journal article VoR https://hiroshima.repo.nii.ac.jp/records/2006463 10.1248/bpb.18.996 https://doi.org/10.1248/bpb.18.996 0918-6158 1347-5215 AA10885497 Biological and Pharmaceutical Bulletin Biological and Pharmaceutical Bulletin 18 7 996 996 1000 https://hiroshima.repo.nii.ac.jp/record/2006463/files/BiolPhamBull_18_996.pdf 832.7 KB