2026-03-13T20:57:18Z https://hiroshima.repo.nii.ac.jp/oai

oai:hiroshima.repo.nii.ac.jp:02006127 2025-04-30T00:20:40Z 1730444907710

Controlling the Magnetic Responsiveness of Cellulose Nanofiber Particles Embedded with Iron Oxide Nanoparticles Bahri, Nur Syakirah Nabilah Saipul Bahri Nur Syakirah Nabilah Saipul Nguyen, Tue Tri Nguyen Tue Tri Matsumoto, Kohei Matsumoto Kohei Watanabe, Mai Watanabe Mai Morita, Yuko Morita Yuko Eka, Lutfi Septiani Eka Lutfi Septiani Cao, Le Anh Kiet Cao Le Anh Kiet Hirano, Tomoyuki Hirano Tomoyuki Ogi, Takashi Ogi Takashi open access This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Bio Materials, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsabm.4c00213 This is not the published version. Please cite only the published version. この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。 TEMPO-Oxidized Cellulose Nanofibers Iron Oxide Nanoparticles Nanostructured Material Spray Drying Functionalized Composite Particles Magnetic Separation Streptavidin-biotin Binding Biomedical Application 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofiber (TOCN) particles, an innovative biobased material derived from wood biomass, have garnered significant interest, particularly in the biomedical field, for their distinctive properties as biocompatible particle adsorbents. However, their microscopic size complicates their separation in liquid media, thereby impeding their application in various domains. In this study, superparamagnetic magnetite nanoparticles (NPs), specifically iron oxide Fe3O4 NPs with an average size of 15 nm, were used to enhance the collection efficiency of TOCN-Fe3O4 composite particles synthesized through spray drying. These composite particles exhibited a remarkable ζ-potential (approximately −50 mV), indicating their high stability in water, as well as impressive magnetization properties (up to 47 emu/g), and rapid magnetic responsiveness within 60 s in water (3 wt % Fe3O4 to TOCN, 1 T magnet). Furthermore, the influence of Fe3O4 NP concentrations on the measurement of the speed of magnetic separation was quantitatively discussed. Additionally, the binding affinity of the synthesized particles for proteins was assessed on a streptavidin–biotin binding system, offering crucial insights into their binding capabilities with specific proteins and underscoring their significant potential as functionalized biomedical materials. American Chemical Society 2024-04-16 eng journal article AM https://hiroshima.repo.nii.ac.jp/records/2006127 https://doi.org/10.1021/acsabm.4c00213 日本学術振興会 23H01745 高次構造ポーラス微粒子創製のプロセスサイエンスの構築と物質移動特性の解明 Japan Society for the Promotion of Science 22K20482 Development of process science for the creation of porous particles with highly-ordered structure and elucidation of mass transfer characteristics 日本学術振興会 23K13590 規則性マクロポーラス酸化物担体を用いた固体高分子形燃料電池の高耐久・高性能化 Japan Society for the Promotion of Science 規則性マクロポーラス酸化物担体を用いた固体高分子形燃料電池の高耐久・高性能化 日本学術振興会 微粒子ナノ構造化技術による燃料電池触媒層の細孔ネットワークエンジニアリング Japan Society for the Promotion of Science Pore Network Engineering of Fuel Cell Catalyst Layers by Particle Nanostructuring Technology ACS Applied Bio Materials 7 5 3227 3227 3237 https://hiroshima.repo.nii.ac.jp/record/2006127/files/ABM_7_3227.pdf 5.3 MB 2025-04-16