2026-03-11T21:59:58Z https://hiroshima.repo.nii.ac.jp/oai

oai:hiroshima.repo.nii.ac.jp:02030236 2025-06-09T04:14:53Z 1727147343679:1730444328970:1730444332102

HAIRY CELL LEUKEMIA (HCL) の 12 症例の細胞学的解析 Cytology in Hairy Cell Leukemia (HCL) 和泉, 堯己 Izumi, Takaki 和泉 Izumi 堯己 Takaki 小村, 堯 Komura, Takashi 小村 Komura 堯 Takashi 久島, 公夫 Kushima, Kimio 久島 Kushima 公夫 Kimio 山下, 美佐子 Yamashita, Misako 山下 Yamashita 美佐子 Misako 田中, 公夫 Tanaka, Kimio 田中 Tanaka 公夫 Kimio 国立情報学研究所 open access Hairy cell leukemia B-cell chromosome aberrations 490 Hairy cell leukemia (HCL) is a chronic lympho-proliferative disease. The disease is clinically characterized by anemia, granulocytopenia, thrombocytopenia, monocytopenia, splenomegaly. This leukemia cells have peculiar shape with hairlike projection, and express mature B-cell antigens such as, CD19,CD20 and Ig heavy chain on their surface. Nuclear and cytoplasm area ratio was low. Cell biological observation and chromosome analysis were performed in 12 patients. Translocation at 14q32 was found in 2 patients and loss of chromosome 6 was found in one patient. These cytogenetical results suggest taht HCL is different disease from chronic lymphocytic leukemia. 広島大学総合科学部 2006-03-21 2000-12-28 jpn departmental bulletin paper VoR https://doi.org/10.15027/903 https://hiroshima.repo.nii.ac.jp/records/2030236 10.15027/903 1340-8364 AN10435936 広島大学総合科学部紀要. IV, 理系編 Memoirs of the Faculty of Integrated Arts and Sciences, Hiroshima University. IV, Science reports 26 63 63 70 https://hiroshima.repo.nii.ac.jp/record/2030236/files/KJ00000197448.pdf 912.9 KB