2026-03-14T09:56:14Z https://hiroshima.repo.nii.ac.jp/oai

oai:hiroshima.repo.nii.ac.jp:02012819 2025-06-02T02:50:06Z 1727147343679:1730442224523:1730442345537

On the Study of Developmental Genetics of Isolated Pulmonary Hypoplasia 肺動脈発育不全に関する発生遺伝学的研究 Satow, Yukio Satow Yukio Okamoto, Naomasa Okamoto Naomasa Yi, Lee Juing Yi Lee Juing Sumida, Hiroshi Sumida Hiroshi open access DHS mice Pdn mice Polydactyly Pulmonary hypoplasia Polygene 490 We have carried out the study on the heart anomalies of the DHS mice and Pdn mice fetuses and newborns which are known to produce genetically induced polydactyly. The results have revealed that the heart anomalies are mainly isolated hypoplasia of the pulmonary artery and that these anomalies are not always associated with polydactyly. The isolated hypoplasia of the pulmonary artery show a tendency to develop among uterine sibilings. These might suggest that the genetic traits of heart anomalies are controlled by the polygenic or multifactorial inheritances. This study has been supported in part by Research Grants from Japanese Ministry of Education on the Experimental study of the morphogenesis of cardiovascular anomaly (448140), and on the Fine structure and pathogenesis of the heart and vessel (511102, Research Director: Professor Naomasa OKAMOTO). Hiroshima University School of Medicine 1982-06-10 eng departmental bulletin paper VoR https://hiroshima.repo.nii.ac.jp/records/2012819 7129955 0018-2052 AA00664312 Hiroshima Journal of Medical Sciences Hiroshima Journal of Medical Sciences 31 2 97 97 102 https://hiroshima.repo.nii.ac.jp/record/2012819/files/HiroshimaJMedSci_31_97.pdf 798.5 KB